Figure 3From: Structure-function analysis of the retinoblastoma tumor suppressor protein – is the whole a sum of its parts? Binding sites for E2Fs and other proliferative control activities. The open reading frame of pRB is shown with locations of the A and B parts of the pocket. Regions of contact that have been mapped for E2F transcription factors, chromatin regulators, and protein degradation machinery that are involved in controlling proliferation are diagramed.Back to article page