The many faces of ubiquitinated histone H2A: insights from the DUBs

Cell Division

Table 1 Mammalian H2A deubiquitinating enzymes (DUBs)

DUB	Domain structure	Substrate	Interactors	Process	Ref.
USP3	ZnF-UBP, UCH	H2A, H2B	n.d.	DNA damage response; S-phase progression	[17]
USP16/UbpM	ZnF-UBP, UCH	H2A	n.d.	Transcription of HoxD10; G2/M transition	[24,33]
USP21	UCH	H2A	n.d.	Transcription	[25]
USP22	ZnF-UBP, UCH	H2A, H2B	SAGA complex	Transcriptional coactivator with Myc, AR, ER, GR; G1/S transition	[28,29]
2A-DUB/KIAA1915/MYSM1	SANT, SWIRM, JAMM/MPN+	H2A	p/CAF, Trip5/KIF11, Rbm10	Transcriptional coactivator with AR	[27]

Abbreviations: ZnF-UBP, Zinc Finger-Ubiquitin Binding Domain; UCH, Ubiquitin C Terminal Hydrolase domain; AR, Androgen Receptor; ER, Estrogen Receptor; GR, Growth hormone Receptor; 2A-DUB, H2A DeUBiquitinase; JAMM, JAB1/MPN/Mov34 metalloenzyme domain; MPN+, Mpr1, Pad1 N-terminal + domain; p/CAF, p300/CBP Associated Factor; n.d., not determined.

ISSN: 1747-1028