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Table 1 Rb-/- mouse models of retinoblastoma

From: Insights from mouse models into human retinoblastoma

Model Frequency Tumor Characteristics References
Rb-/-p107-/- chimeras 5/7 mice (1/5 bilateral) Positive staining for amacrine markers, some Müller cells present [65]
Rb-/-p130-/- chimeras 5/11 mice (2/5 bilateral) Positive staining for amacrine markers, some Müller cells present
Average 3 months to tumor detection
[71]
α-Cre; Rb lox/lox ; p107-/- > 60% Positive staining for amacrine markers, some Müller cells present
Average 280 days to externally visible retinoblastoma
[67, 68]
α-Cre; Rb lox/lox ; p130-/- 29/29 mice (bilateral) Positive staining for amacrine and horizontal markers, some
Müller cells present
Average 128 days to externally visible retinoblastoma
Lymph node and brain metastasis
[68]
NesCre1; Rb lox/lox ; p130-/- 5/5 mice (4/5 bilateral) Positive staining for amacrine markers, some Müller cells present [69]
Chx10Cre; Rb lox/lox ; p107-/- ~60% Positive staining for amacrine, horizontal and progenitor markers [89]
Chx10Cre; Rb lox/lox ; p107-/-; p53-/- 100% (bilateral) Positive staining for amacrine, horizontal and progenitor markers
Increase in less differentiated cells vs. Chx10Cre; Rblox/lox
p107-/- tumors
Average 100 days before mice were moribund
[70, 89, 129]
Chx10Cre; Rb lox/lox ; p130-/-;p107+/- 45/45 mice (bilateral) Positive staining for horizontal cell markers in primary tumors
Metastastes did not stain for horizontal cell markers
Tumors arose at 8-14 weeks
[95]