Table 1 Rb-/- mouse models of retinoblastoma

Rb-/-p107-/- chimeras

5/7 mice (1/5 bilateral)

Positive staining for amacrine markers, some Müller cells present

[65]

Rb-/-p130-/- chimeras

5/11 mice (2/5 bilateral)

Positive staining for amacrine markers, some Müller cells present

Average 3 months to tumor detection

[71]

α-Cre; Rb ^lox/lox ; p107-/-

> 60%

Positive staining for amacrine markers, some Müller cells present

Average 280 days to externally visible retinoblastoma

[67, 68]

α-Cre; Rb ^lox/lox ; p130-/-

29/29 mice (bilateral)

Positive staining for amacrine and horizontal markers, some

Müller cells present

Average 128 days to externally visible retinoblastoma

Lymph node and brain metastasis

[68]

NesCre1; Rb ^lox/lox ; p130-/-

5/5 mice (4/5 bilateral)

Positive staining for amacrine markers, some Müller cells present

[69]

Chx10Cre; Rb ^lox/lox ; p107-/-

~60%

Positive staining for amacrine, horizontal and progenitor markers

[89]

Chx10Cre; Rb ^lox/lox ; p107-/-; p53-/-

100% (bilateral)

Positive staining for amacrine, horizontal and progenitor markers

Increase in less differentiated cells vs. Chx10Cre; Rblox/lox

p107-/- tumors

Average 100 days before mice were moribund

[70, 89, 129]

Chx10Cre; Rb ^lox/lox ; p130-/-;p107+/-

45/45 mice (bilateral)

Positive staining for horizontal cell markers in primary tumors

Metastastes did not stain for horizontal cell markers

Tumors arose at 8-14 weeks

[95]