Figure 4From: A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombe Chk1 is activated in rid1-1 and rid2-1. (A) Chk1 phosphorylation occurs in both rid1-1 and rid2-1 strains at 29°C and 25°C, respectively. (B) rid1-1 viability is dependent on expression of mrc1+(C) rid1-1 and rid2-1 are not hypersensitive to hydroxyurea treatment as compared to Δmrc1.Back to article page