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Table 3 Cancers in which Jab1/CSN5 is overexpressed and its association with p27 and clinical outcome

From: JAB1/CSN5: a new player in cell cycle control and cancer

Tumor type Associated with poor outcome Negative Correlation with p27 References
Pituitary tumor No Yes [121]
Pancreatic adenocarcinoma Yes Yes [100, 122]
Oral squamous cell carcinoma Yes Yes [123, 124]
Epithelial ovarian tumors Yes Yes [125, 126]
Neuroblastoma ND ND [127]
Embryonal rhabdomyosarcoma No Yes [128]
Hepatocellular carcinoma ND Yes [83, 97, 107]
Intrahepatic Cholangiocarcinomas No No [129]
Laryngeal squamous cell carcinoma Yes Yes [130]
Esophageal squamous cell carcinoma Yes Yes [131]
Metastatic melanoma ND Yes [132]
Invasive breast carcinoma Yes Yes [92, 93]
ERalpha-negative breast cancer No No [98]
Systemic anaplastic large cell lymphoma ND Yes [133]
Non-Hodgkin's lymphoma Yes Yes [134]
Malignant lymphoma of the thyroid ND Yes [135]
Thyroid medullary carcinoma No Yes [136]
Papillary Thyroid Carcinoma Yes ND [137]
Non-small-cell lung cancer Yes Yes [138, 139]
  1. Abbreviation: ND, not determined