Table 3 Cancers in which Jab1/CSN5 is overexpressed and its association with p27 and clinical outcome
From: JAB1/CSN5: a new player in cell cycle control and cancer
Tumor type | Associated with poor outcome | Negative Correlation with p27 | References |
|---|---|---|---|
Pituitary tumor | No | Yes | [121] |
Pancreatic adenocarcinoma | Yes | Yes | |
Oral squamous cell carcinoma | Yes | Yes | |
Epithelial ovarian tumors | Yes | Yes | |
Neuroblastoma | ND | ND | [127] |
Embryonal rhabdomyosarcoma | No | Yes | [128] |
Hepatocellular carcinoma | ND | Yes | |
Intrahepatic Cholangiocarcinomas | No | No | [129] |
Laryngeal squamous cell carcinoma | Yes | Yes | [130] |
Esophageal squamous cell carcinoma | Yes | Yes | [131] |
Metastatic melanoma | ND | Yes | [132] |
Invasive breast carcinoma | Yes | Yes | |
ERalpha-negative breast cancer | No | No | [98] |
Systemic anaplastic large cell lymphoma | ND | Yes | [133] |
Non-Hodgkin's lymphoma | Yes | Yes | [134] |
Malignant lymphoma of the thyroid | ND | Yes | [135] |
Thyroid medullary carcinoma | No | Yes | [136] |
Papillary Thyroid Carcinoma | Yes | ND | [137] |
Non-small-cell lung cancer | Yes | Yes |