Human linker histones: interplay between phosphorylation and O-β-GlcNAc to mediate chromatin structural modifications

Ahmad, Waqar; Shabbiri, Khadija; Nazar, Noreen; Nazar, Shazia; Qaiser, Saba; Shabbir Mughal, Mirza Abid

doi:10.1186/1747-1028-6-15

Table 1 Phosphorylation and O-β-GlcNAc site map of Homo sapiens

From: Human linker histones: interplay between phosphorylation and O-β-GlcNAc to mediate chromatin structural modifications

Substrate		Phosphorylation Sites by NetPhos	Experimentally known	Predicted by Motif	Yin Yang sites	Conserved	Conserved sub
H1.1	SER	33, 41, 51, 52, 53, 91, 106, 114, 115, 123, 135, 145, 148, 164, 165	1, 35, 103, 183	183	33, 52, 53, 114, 164, 165	41, 43, 51, 53, 60, 106, 183	1, 48, 52, 91, 103
	THR	94, 151, 161, 173, 199, 203	151	151	161, 173, 199, 203	94	101, 151, 11, 164, 203
H1.2	SER	35, 50, 54, 104, 112, 149, 172, 187	1, 172	172	30, 50, 187	1, 40, 58, 77, 102, 104, 172, 187	35, 85, 88, 112
	THR	30, 91, 145, 153, 166	30	30, 145, 153	145, 166	44, 91, 95, 98	3, 153
H1.3	SER	36,51, 55, 104, 113, 150, 173, 188, 204	188	173, 188	35, 51, 188, 204	36, 41, 51, 58, 79, 89, 102, 104, 188	1, 86
	THR	18, 92, 146, 154, 167, 179	18	18, 146, 154	146	3, 45, 92, 96, 99	154
H1.4	SER	26, 35, 50, 54, 103, 112, 150, 171, 186	35, 171, 186	171, 186	35, 50, 186	1, 35, 40, 50, 54, 57, 78, 85, 88, 101, 103, 112, 150, 171, 186	172, 188
	THR	17, 91, 145, 153, 202	17	17, 145, 153	17, 145, 202	3, 17, 91, 95, 98, 145	141, 153, 202
H1.5	SER	17, 43, 53, 106, 115, 172, 188	17, 172, 188	17, 172	17, 43, 53	1, 43, 60, 80, 104, 106, 115	17, 53, 88, 91, 172
	THR	10, 24, 38, 94, 137, 154	137,154	10, 137, 154	10, 38	38	3, 8, 47, 98, 101, 154
H1.0	SER	6, 18, 21, 44, 48, 65, 70, 97, 103, 123, 130, 185	123		6, 21, 44, 97, 103, 123, 130	4, 6, 21, 28, 44, 45, 55, 65, 70, 89, 91, 103, 130, 170, 184, 185	18, 97, 115
	THR	109, 118, 134, 140, 152, 161		118, 140, 152	134, 161	1, 5, 22, 76, 77, 83, 109, 118, 123, 134, 140, 152	161
H1.T	SER	8, 42, 52, 54, 86, 107, 111, 118, 126, 128, 137, 140, 142, 165, 180, 187, 204	177	142, 180	8, 54, 118, 180, 204	1,42, 44, 52, 54,61,81, 105,107,140, 142,165, 180	8, 35, 126, 128, 137, 187, 189, 204
	THR	131, 148, 158, 159, 162, 203	158, 159		148, 158, 159, 162, 203	3, 21, 99, 102, 148, 158	10, 48, 131, 145, 203
H1oo	SER	8, 11, 13, 14, 16, 20, 21, 23, 26, 32, 42, 73, 161, 211, 229, 230, 235, 243, 245, 246, 260, 262, 263, 276, 336, 337, 340, 341		276	8, 13, 14, 16, 26, 73, 229, 262, 336, 337, 340, 341	5, 8, 12, 13, 20, 67, 110, 118, 221, 236	7, 122, 219, 231, 241, 249
	THR	72, 194, 256, 278, 319			256, 319	66, 81, 97, 116, 231	19, 209
H1.X	SER	31, 33, 39, 92, 113, 154, 171	31, 33		33	49, 65, 66, 92, 113,	27, 31, 133
	THR	55				101	12, 13, 55, 87

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ISSN: 1747-1028

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