Table 3 Functions associated with the top four group of genes (Figures 3, 4 ) whose expression was affected by treatment with guieranone A in CCRF-CEM cancer cell lines

1

50

28

Molecular transport, Protein trafficking, Cellular assembly and organization

ACP1, ATP1A1, DDX21, DDX3X, DOK2, ERK1/2, GC-GCR dimer, GNL3, Histone h3, Histone h4, HNRNPH1, HNRNPK, Importin alpha, Importin beta, KPNA2, KPNB1, LARP1, LYAR, NCL, NDRG1, NUP62, NUP153, RANBP1, Rnr, RRP1B, RRS1, SLBP, THOC4, TNFRSF8, TNPO1, TPX2, TSC22D3, TSR1, WDR12, YBX1

2

50

28

Drug metabolism, endocrine System development and function, lipid metabolism

ACTB, Actin, ACTL6A, Akt, alcohol group acceptor phosphotransferase, CS, FASN, HMGA1, HNRNPL, HSP90AB1, IARS, IKK (complex), IPO4, KEAP1, Lamin b, MAP3K8, MCM3, MCM4, MORF4L2, MYCN, ORC6L, PDCD6IP, PSMD6, PTGES3 (includes EG:10728), RNF4, RPL6, RPL7A (includes EG:6130), RPS24 (includes EG:6229), RUVBL1, SGK1, SLC38A2, SMC3, Thyroid hormone receptor, TIP60, TUBB

3

47

27

Cell death, cell-to-cell signaling and interaction, cellular function and maintenance

14-3-3, ACAT2, AHCY, APIP, ARF3, CD3, CD52, CTPS, FAM83D, FOSB, FOXO3, GADD45B, HBP1, HNRNPAB, HSPA6, IL10RB, Immunoglobulin, KIF23, LMNB1, Mapk, Mek, MVP, PDGF BB, Pld, PPHLN1, PPP1R15A, PRDX3, PRKCB, RBCK1, RGS2, TCR, UTP14A, VIM, YWHAE, YWHAG

4

45

26

Cell cycle, cancer, gastrointestinal disease

ADAR, APC, CCNA2, CDK1, CDKN3, CHEK1, CNOT7, Cyclin A, DHFR, E2f, FBXO5, FEN1, H2AFY, ID2, IFI16, KIAA0101, MAD2L1, MAP2K1/2, methenyltetrahydrofolate cyclohydrolase, methylenetetrahydrofolate dehydrogenase (NADP), Mre11, MTHFD1, MTHFD2, MTHFD1L, NBN, NUSAP1, PI3K (complex), PRIM1, Rb, RFC4, TFDP1, TINF2, TYMS, WEE1, XRCC5