Figure 2

GO Cellular Component clusters for human centrosome proteins. The subcellular localizations of the 599 centrosome candidate proteins were extracted with the Database for Annotation, Visualization and Integrated Discovery (DAVID), version 6.7 [48] using the Gene Ontology (GO) term ‘’Cellular Component”. The distribution of proteins over 9 main clusters (“actin cytoskeleton”, light blue; “MT cytoskeleton”, blue; “chromosome”, purple; “nuclear lumen”, red; “cell projection”, green; “centrosome”, orange; “other”, grey; “golgi apparatus”, deep red; “vesicle”, yellow) is illustrated as pie chart and the number of proteins annotated for each GO term is indicated. Subclusters within 7 of the 9 main clusters are shown in the respective colors and the number of proteins annotated for each GO term is indicated in parenthesis. Note that pie charts are simplified representations that do not reflect 100%. Proteins can have multiple annotations or no annotation. This is not illustrated in the charts.