Autonomic nerve activity contributes to the tumor progression and metastasis.
Go Yoshida, Tokyo Medical and Dental University
13 November 2014
As evidenced by the recent research article (Science.2013;341:1236361), the blockage of beta-adrenergic receptor signal is a promising therapeutic strategy to prevent the tumor-associated neurogenesis as well as angiogenesis. While adrenergic sympathetic neurons maintain the survival signal of tumor cells at the carcinogenesis phase, cholinergic parasympathetic nerves infiltrate into the tumor tissue and promote tumor dissemination and metastasis via stromal Chrm1 expression.
Autonomic nerve activity contributes to the tumor progression and metastasis.
13 November 2014
As evidenced by the recent research article (Science.2013;341:1236361), the blockage of beta-adrenergic receptor signal is a promising therapeutic strategy to prevent the tumor-associated neurogenesis as well as angiogenesis. While adrenergic sympathetic neurons maintain the survival signal of tumor cells at the carcinogenesis phase, cholinergic parasympathetic nerves infiltrate into the tumor tissue and promote tumor dissemination and metastasis via stromal Chrm1 expression.
Competing interests
No competing interests exist.