Fig. 4From: The role of cullin 5-containing ubiquitin ligasesDegradation of APOBEC3 by the HIV Vif protein. APOBEC3 introduces nonsense and/or missense mutations in the HIV genome, thereby showing antivirus activity. The HIV-1 Vif protein forms a complex with Cul5, the Elongin B/C heterodimer, Rbx2, E2, ubiquitin (Ub), and CBF-β. The Vif complex targets APOBEC3 for polyubiquitination and proteasomal degradationBack to article page