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Fig. 4 | Cell Division

Fig. 4

From: The role of cullin 5-containing ubiquitin ligases

Fig. 4

Degradation of APOBEC3 by the HIV Vif protein. APOBEC3 introduces nonsense and/or missense mutations in the HIV genome, thereby showing antivirus activity. The HIV-1 Vif protein forms a complex with Cul5, the Elongin B/C heterodimer, Rbx2, E2, ubiquitin (Ub), and CBF-β. The Vif complex targets APOBEC3 for polyubiquitination and proteasomal degradation

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