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Table 1 Known CRL2 complexes and their substrates

From: The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions

Ubiquitin ligase Interaction domain Substrates Reference
VHL VHL box HIFα [15]
Spry2 [6]
Rpb1 [7, 8]
Rpb7 [9]
Atypical PKC (PKCλ and ζII) [10, 11]
EGFR [12]
LRR-1 VHL box CKI-1 (C. elegans) [1315]
p21CIP [15]
HTP3 (C. elegans) [16]
FEM1/Fem1B VHL box TRA-1(C. elegans) [17]
Gli1 [18]
Ankrd37 (mouse) [19]
Prame VHL box unknown [20, 21]
ZYG-11/ZER1 VHL box unknown [22, 23]
BAF250/Osa/BAF250b BC box H2B [24]
Rack1 BC box-like HIF-1α [25]
BimEL [26]
Ad E4orf6 BC box p53 [2730]
Mre11 [2931]
DNA ligase IV [29, 30, 32]
Intergrin α3 [29, 30, 33]
TOPBP1 [29, 34]
EBV Bzlf1 Cul2 box p53 [3537]
HPV16 E7 incomplete Cul2 box pRB [3841]
BIV Vif BC box A3Z2-Z3 (Bos taurus) [42, 43]
Unknown Unknown RhoB [44]