The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions

Cell Division

Table 1 Known CRL2 complexes and their substrates

Ubiquitin ligase	Interaction domain	Substrates	Reference
VHL	VHL box	HIFα	[1–5]
		Spry2	[6]
		Rpb1	[7, 8]
		Rpb7	[9]
		Atypical PKC (PKCλ and ζII)	[10, 11]
		EGFR	[12]
LRR-1	VHL box	CKI-1 (C. elegans)	[13–15]
		p21CIP	[15]
		HTP3 (C. elegans)	[16]
FEM1/Fem1B	VHL box	TRA-1(C. elegans)	[17]
		Gli1	[18]
		Ankrd37 (mouse)	[19]
Prame	VHL box	unknown	[20, 21]
ZYG-11/ZER1	VHL box	unknown	[22, 23]
BAF250/Osa/BAF250b	BC box	H2B	[24]
Rack1	BC box-like	HIF-1α	[25]
Rack1	BC box-like	BimEL	[26]
Ad E4orf6	BC box	p53	[27–30]
		Mre11	[29–31]
		DNA ligase IV	[29, 30, 32]
		Intergrin α3	[29, 30, 33]
		TOPBP1	[29, 34]
EBV Bzlf1	Cul2 box	p53	[35–37]
HPV16 E7	incomplete Cul2 box	pRB	[38–41]
BIV Vif	BC box	A3Z2-Z3 (Bos taurus)	[42, 43]
Unknown	Unknown	RhoB	[44]

ISSN: 1747-1028