Protein arginine methylation: an emerging regulator of the cell cycle

Cell Division

Table 2 Key DNA damage repair proteins known to be substrates and interacting partners of PRMTs

Protein	Interacting PRMT	Known methylated residues	Result of methylation or PRMT interaction	Refs.
DNA polymerase β	PRMT1	R137	Regulates binding to proliferating cell nuclear antigen	[142]
DNA polymerase β	PRMT6	R83, R152	Enhances DNA binding affinity of DNA polymerase β and enhances repair ability	[144]
FEN1	Unknown	R192	Enhances localization to DNA repair sites and binding to PCNA	[145]
hnRNPUL1	PRMT1	R584, 5618, R620, R645, R656	Regulates interaction with NBS1 and recruitment to DNA damage site	[137]
MRE11	PRMT1	–	Regulation of DNA exonuclease activity	[138, 139]
p53BP1	PRMT1	R1400, R1401, R1403	Enhanced localisation to DNA damage sites	[140]
Rad9	PRMT5	R172, R174, R175	Regulation of checkpoint activation	[143]

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