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Fig. 4 | Cell Division

Fig. 4

From: IMP/GTP balance modulates cytoophidium assembly and IMPDH activity

Fig. 4

Mutations on CBS domain prevent cytoophidium assembly. a Mutant cell lines were treated with 1 mM ribavirin for 4 h and probed with mouse monoclonal anti-IMPDH1 and rabbit polyclonal anti-IMPDH2 antibody to evidence the no-filament phenotype. The arrows in indicate the previously described intranuclear filaments. b Cell lines with endogenous mutations induced by CRISPR/Cas9 system on IMPDH2 gene. Sequences showing the genotype of each cell line

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