Table 1 Autodock scores and affinity values for the interaction between 3,4,4′-TMS, 3,5,4′-TMS, combretastatin A4 or colchicine and γ/γ-tubulin (γ/γ) or α/β-tubulin (α/β) dimers
ΔG (γ/γ) | Kd (γ/γ) | ΔG (α/β) | Kd (α/β) | ΔG (α/β)/ ΔG (γ/γ) | Kd (α/β)/ Kd (γ/γ) | |
|---|---|---|---|---|---|---|
3,4,4′-TMS | − 7.36 | 4.023 | − 6.35 | 22.128 | 0.863 | 5.501 |
3,5,4′-TMS | − 7.02 | 7.141 | − 6.37 | 21.393 | 0.907 | 2.996 |
Combretastatin A4 | − 6.07 | 35.498 | − 6.72 | 11.849 | 1.107 | 0.334 |
Colchicine | − 7.27 | 4.683 | − 9.91 | 0.054 | 1.363 | 0.012 |