MPS1 is involved in the HPV16-E7-mediated centrosomes amplification

Cell Division

Table 1 In silico analysis of MPS1 and PLK4 phosphorylation sites

A) MPS1	PLK4 aminoacid	Aminoacid in protein	Score	Domain
	T384	Exposed	4.12
	T393	Exposed	4.25
Autophosphorylation [43]	S282	Exposed	6.27	Pest 1
Autophosphorylation [43]	T295	Exposed	5.43	Pest 1

B) PLK4	MPS1 aminoacid	Aminoacid in protein	Score	Domain
	S108	Exposed	6.66
	S709	Exposed	6.66	Kinase
	T849	Exposed	5
Autophosphorylation [44]	T676	Exposed	5.62	Kinase

A Two possible residues exposed in the PLK4 kinase that can be phosphorylated by MPS1 (T384 and T393). B Three possible residues exposed in the MPS1 kinase that can be phosphorylated by PLK4 (S108, S709, and T849)

ISSN: 1747-1028