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Table 1 Percentage of breast cancer patients with dysregulated expression of TTK and TBK1

From: Ethnic and racial-specific differences in levels of centrosome-associated mitotic kinases, proliferative and epithelial-to-mesenchymal markers in breast cancers

TCGA

METABRIC

Subtype

N

% TTK over-expressed

% TBK1 over-expressed

% TBK1 under-expressed

N

% TTK over-expressed

% TBK1 over-expressed

% TBK1 under-expressed

All

996

6.6

8.0

2.2

1904

5.1

5.9

3.3

Basal

171

31.6

2.3

5.3

199

32.2

2

12.0

HER2 + 

78

3.8

6.4

3.8

220

7.7

6.8

2.7

Luminal A

499

0.0

6.0

1.8

679

0.0

3.4

1.3

Luminal B

197

4.6

18.8

0

461

0.7

11.5

1.1

Normal

36

0.0

0

2.8

140

0.0

2.9

6.4

Non-classified

15

0.0

26.7

0

6

0.0

0.0

0.0

Claudin-Low

N/A

N/A

N/A

N/A

199

6.5

6.5

4.5

  1. Gene expression of TTK, TBK1, and Nek2 mRNAs from basal breast cancers using TCGA and METABRIC datasets from cBioPortal. Analysis used n = 2509 samples from METABRIC and n = 1084 TCGA samples. A z-score threshold of ± 2.0 was used for optimal results
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Cell Division

ISSN: 1747-1028

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