Ethnic and racial-specific differences in levels of centrosome-associated mitotic kinases, proliferative and epithelial-to-mesenchymal markers in breast cancers

Table 2 Average expression per patient (standard deviation) as a function of race (TCGA) Average expression of TTK, Nek2, and TBK1 by subtype, race, and ethnicity using the TCGA database

Subtype	Race	Number of cases	TTK levels^a	NEK2 levels^a	TBK1 levels^a
All subtypes	NHB	182	0.19 (0.99)^b	1.20 (1.78)^c	− 0.36 (1.48)
	NHW	749	− 0.02 (1.01)	0.78 (1.63)	0.29 (1.57)^d
	H/L	38	− 0.07 (0.88)	0.66 (1.72)	.05 (1.29)
	Non-H/L	875	0.07 (1.08)	0.9 (1.67)^d	0.2 (1.7)
Basal	NHB	53	1.09 (0.94)	2.35 (1.8)	− 0.85 (1.09)
	NHW	106	1.6 (1.32)^b	2.03 (1.75)	− 0.27 (1.28)^b
	H/L	3	2.6 (0.05)^d	2.9 (1.47)	− 0.78 (0.02)
	Non-H/L	149	1.5 (1.4)	2.2 (1.79)	− 0.42 (1.27)
Luminal A	NHB	56	− 0.51 (0.33)	0.18 (1.03)	− 0.36 (1.23)
	NHW	384	− 0.51 (0.32)	0.14 (1.04)	0.30^d (1.47)
	H/L	22	− 0.23 (0.44)^b	1.74 (2.18)	0.14 (0.9)
	Non-H/L	403	− 0.51 (0.3)	2.05 (1.60)	0.22 (1.5)
Other	NHB	23	0.28 (1.14)^b	1.5 (2.19)^b	− 0.33 (2.35)
	NHW	71	− 0.47 (0.46)	0.06 (1.23)	− 0.15 (1.71)
	H/L	7	− 0.45 (0.41)	− 0.28 (0.4)	0.04 (1.9)
	Non-H/L	79	− 0.46 (0.80)	− 0.03 (1.63)	− 0.53 (1.86)

^amRNA Expression normalized to diploid samples (standard deviation of the population) from cBIOPORTAL/TCGA. A z-score threshold ± 2.0 was used for optimal results. P-values were done by T-test (2-tails, unequal variance)
^bP ≤ 0.05
^cP ≤ 0.005
^dP ≤ 0.0005 from a T-test with 2-tails and unequal variance

ISSN: 1747-1028