Table 1 Similar or different biological functions among MST kinases

Similarities (MST1-4 and YSK1)

Cytoskeleton organization

[2]

Cell polarity and migration

[9]

Apoptosis

[10, 11]

Proliferation and migration of cancer cells

Immune regulation

[12, 13]

[14]

CNS development

[5]

Differences

MST1/MST4

Autophagy

[12, 15, 16]

MST1/2

Glycogen storage

[17]

MST1/2

Stem cell function

[18]

MST1/YSK1

Pancreatic cell homeostasis, and insulin secretion

[2]

MST1/3/4/5

Lipid metabolism

[2, 9]

MST3

Hypertension

[19, 20]

MST4

Radioresistance

[12]

YSK1

Golgi integrity

[21]