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Erratum to: Electrostatic forces drive poleward chromosome motions at kinetochores
© The Author(s) 2017
- Received: 3 April 2017
- Accepted: 3 April 2017
- Published: 3 July 2017
The original article was published in Cell Division 2016 11:14
In particular, since C-termini are on the outsides of microtubules, as the curvature of splaying microtubule protofilaments increases, the electrostatic attractions between charges on Hec1 tails and C-termini will weaken and fail because of the loss of close proximity between the two charge distributions.
This situation is detailed in Fig. 1a, which shows a time sequence between force-generating gently splaying protofilaments, and the later failure of these protofilaments to interact electrostatically because of the geometry effect of increased protofilament curvature.
As depicted in the top microtubule in Fig. 1a, since C-termini are on the concave sides of progressively splaying microtubules, increasing protofilament curvature will lead to a separation of the charges on Hec1 tails and C-termini. Accordingly, subsets of low-curvature splaying protofilaments generate poleward force, while other subsets of protofilaments with more pronounced curvature in later stages of depolymerization will fail to bind. Thus poleward force is generated as microtubules depolymerize, in agreement with observation.
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