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Correction to: Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells

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The original article was published in Cell Division 2018 13:10

Correction to: Cell Div (2018) 13:10 https://doi.org/10.1186/s13008-018-0043-3

The authors note a correction to the article [1]. Figure 1d of the original article has an error. The pcDNA3/Ctrl and the pcDNA3-TAp73a/DMSO wells are duplicated. This article presents the corrected version of Fig. 1.

Fig. 1
figure1

PpIX inhibits proliferation of cancer cells lacking p53. a Schematic representation of the splice variants in TP73 gene (upper panel) and domain structure of p73 (lower panel). TA transactivation domain, DBD DNA binding domain, OD oligomerization domain, CTC terminus. b PpIX induces dose-dependent growth inhibition in a long-term proliferation assay. c Ectopic expression of TAp73α sensitizes cells to PpIX after 24 h as demonstrated by WST-1 proliferation assay. Inserted blot represents the level of expression of TAp73α. Please note that the blot has been cropped. Dotted line represents where the blot has been cut. The uncropped full length version is presented in Additional file 3: Figure S3a. d TAp73α overexpression sensitizes H1299 to PpIX-induced inhibition of proliferation. e, f PpIX does not induce DNA damage in cancer cells at the effective therapeutic concentrations. g 2.5 μg/ml PpIX induces PARP-1 cleavage in HCT 116 p53−/− but not in non-transformed human diploid fibroblasts. Dotted line represents where the blot has been cut. The uncropped blot is presented in Additional file 3: Figure S3b

Reference

  1. 1.

    Sznarkowska A, Kostecka A, Kawiak A, Acedo P, Lion M, Inga A, Zawacka-Pankau J. Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells. Cell Div. 2018;13:10. https://doi.org/10.1186/s13008-018-0043-3.

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Correspondence to Joanna Zawacka‑Pankau.

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