Moberg KH, Bell DW, Wahrer DC, Haber DA, Hariharan IK: Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature 2001,413(6853):311–316. 10.1038/35095068
Article
CAS
PubMed
Google Scholar
Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJ: Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 2001,294(5540):173–177. 10.1126/science.1065203
Article
CAS
PubMed
Google Scholar
Strohmaier H, Spruck CH, Kaiser P, Won KA, Sangfelt O, Reed SI: Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 2001,413(6853):316–322. 10.1038/35095076
Article
CAS
PubMed
Google Scholar
Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, Clurman BE: The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci U S A 2004,101(24):9085–9090. 10.1073/pnas.0402770101
Article
CAS
PubMed Central
PubMed
Google Scholar
Yada M, Hatakeyama S, Kamura T, Nishiyama M, Tsunematsu R, Imaki H, Ishida N, Okumura F, Nakayama K, Nakayama KI: Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. Embo J 2004,23(10):2116–2125. 10.1038/sj.emboj.7600217
Article
CAS
PubMed Central
PubMed
Google Scholar
Moberg KH, Mukherjee A, Veraksa A, Artavanis-Tsakonas S, Hariharan IK: The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Curr Biol 2004,14(11):965–974. 10.1016/j.cub.2004.04.040
Article
CAS
PubMed
Google Scholar
Nateri AS, Riera-Sans L, Da Costa C, Behrens A: The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science 2004,303(5662):1374–1378. 10.1126/science.1092880
Article
CAS
PubMed
Google Scholar
Hubbard EJ, Wu G, Kitajewski J, Greenwald I: sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev 1997,11(23):3182–3193.
Article
CAS
PubMed Central
PubMed
Google Scholar
Wu G, Hubbard EJ, Kitajewski JK, Greenwald I: Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin. Proc Natl Acad Sci U S A 1998,95(26):15787–15791. 10.1073/pnas.95.26.15787
Article
CAS
PubMed Central
PubMed
Google Scholar
Sundqvist A, Bengoechea-Alonso MT, Ye X, Lukiyanchuk V, Jin J, Harper JW, Ericsson J: Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Cell Metab 2005,1(6):379–391. 10.1016/j.cmet.2005.04.010
Article
CAS
PubMed
Google Scholar
Nash P, Tang X, Orlicky S, Chen Q, Gertler FB, Mendenhall MD, Sicheri F, Pawson T, Tyers M: Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature 2001,414(6863):514–521. 10.1038/35107009
Article
CAS
PubMed
Google Scholar
Kimura T, Gotoh M, Nakamura Y, Arakawa H: hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53. Cancer Sci 2003,94(5):431–436. 10.1111/j.1349-7006.2003.tb01460.x
Article
CAS
PubMed
Google Scholar
Welcker M, Orian A, Grim JE, Eisenman RN, Clurman BE: A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size. Curr Biol 2004,14(20):1852–1857. 10.1016/j.cub.2004.09.083
Article
CAS
PubMed
Google Scholar
Spruck CH, Strohmaier H, Sangfelt O, Muller HM, Hubalek M, Muller-Holzner E, Marth C, Widschwendter M, Reed SI: hCDC4 gene mutations in endometrial cancer. Cancer Res 2002,62(16):4535–4539.
CAS
PubMed
Google Scholar
Minella AC, Clurman BE: Mechanisms of tumor suppression by the SCF(Fbw7). Cell Cycle 2005,4(10):1356–1359.
Article
CAS
PubMed
Google Scholar
Orlicky S, Tang X, Willems A, Tyers M, Sicheri F: Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase. Cell 2003,112(2):243–256. 10.1016/S0092-8674(03)00034-5
Article
CAS
PubMed
Google Scholar
Won KA, Reed SI: Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. Embo J 1996,15(16):4182–4193.
CAS
PubMed Central
PubMed
Google Scholar
Clurman BE, Sheaff RJ, Thress K, Groudine M, Roberts JM: Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev 1996,10(16):1979–1990.
Article
CAS
PubMed
Google Scholar
Welcker M, Singer J, Loeb KR, Grim J, Bloecher A, Gurien-West M, Clurman BE, Roberts JM: Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. Mol Cell 2003,12(2):381–392. 10.1016/S1097-2765(03)00287-9
Article
CAS
PubMed
Google Scholar
Ye X, Nalepa G, Welcker M, Kessler BM, Spooner E, Qin J, Elledge SJ, Clurman BE, Harper JW: Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase. J Biol Chem 2004,279(48):50110–50119. 10.1074/jbc.M409226200
Article
CAS
PubMed
Google Scholar
Welcker M, Clurman BE: The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with Fbw7/hCdc4. J Biol Chem 2005,280(9):7654–7658. 10.1074/jbc.M413377200
Article
CAS
PubMed
Google Scholar
Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG Jr.: The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell 2005,8(1):25–33. 10.1016/j.ccr.2005.06.005
Article
CAS
PubMed
Google Scholar
Meimoun A, Holtzman T, Weissman Z, McBride HJ, Stillman DJ, Fink GR, Kornitzer D: Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCF(CDC4) ubiquitin-ligase complex. Mol Biol Cell 2000,11(3):915–927.
Article
CAS
PubMed Central
PubMed
Google Scholar
Henchoz S, Chi Y, Catarin B, Herskowitz I, Deshaies RJ, Peter M: Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast. Genes Dev 1997,11(22):3046–3060.
Article
CAS
PubMed Central
PubMed
Google Scholar
Perkins G, Drury LS, Diffley JF: Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis. Embo J 2001,20(17):4836–4845. 10.1093/emboj/20.17.4836
Article
CAS
PubMed Central
PubMed
Google Scholar
Jackson LP, Reed SI, Haase SB: Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6. Mol Cell Biol 2006,26(6):2456–2466. 10.1128/MCB.26.6.2456-2466.2006
Article
CAS
PubMed Central
PubMed
Google Scholar
Benito J, Martin-Castellanos C, Moreno S: Regulation of the G1 phase of the cell cycle by periodic stabilization and degradation of the p25rum1 CDK inhibitor. Embo J 1998,17(2):482–497. 10.1093/emboj/17.2.482
Article
CAS
PubMed Central
PubMed
Google Scholar
Kominami K, Ochotorena I, Toda T: Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase. Genes Cells 1998,3(11):721–735. 10.1046/j.1365-2443.1998.00225.x
Article
CAS
PubMed
Google Scholar
Suzuki H, Chiba T, Suzuki T, Fujita T, Ikenoue T, Omata M, Furuichi K, Shikama H, Tanaka K: Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination. J Biol Chem 2000,275(4):2877–2884. 10.1074/jbc.275.4.2877
Article
CAS
PubMed
Google Scholar
Yeh E, Cunningham M, Arnold H, Chasse D, Monteith T, Ivaldi G, Hahn WC, Stukenberg PT, Shenolikar S, Uchida T, Counter CM, Nevins JR, Means AR, Sears R: A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol 2004,6(4):308–318. 10.1038/ncb1110
Article
CAS
PubMed
Google Scholar