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  1. Content type: Research

    The S-phase checkpoint aims to prevent cells from generation of extensive single-stranded DNA that predisposes to genome instability. The S. cerevisiae complex Tof1/Csm3/Mrc1 acts to restrain the replicative MCM ...

    Authors: Sonya Dimitrova Uzunova, Alexander Stefanov Zarkov, Anna Marianova Ivanova, Stoyno Stefanov Stoynov and Marina Nedelcheva Nedelcheva-Veleva

    Citation: Cell Division 2014 9:4

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  2. Content type: Research

    Centrosome amplification (CA) amongst particular breast cancer subtypes (Her2+ subtype) is associated with genomic instability and aggressive tumor phenotypes. However, changes in signaling pathways associated...

    Authors: Mi-Young Lee, Mihaela Marina, Jamie L King and Harold I Saavedra

    Citation: Cell Division 2014 9:3

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  3. Content type: Research

    Smurf2 is a member of the HECT family of E3 ubiquitin ligases that play important roles in determining the competence of cells to respond to TGF- β/BMP signaling pathway. However, besides TGF-β/BMP pathway, Sm...

    Authors: Diana David, Sankar Jagadeeshan, Ramkumar Hariharan, Asha Sivakumari Nair and Radhakrishna Madhavan Pillai

    Citation: Cell Division 2014 9:2

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  4. Content type: Short report

    Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylation of downstream effectors. Metnase (also termed SETMAR) is a SET histone methylase and transposase nuclease protein that p...

    Authors: Elizabeth A Williamson, Yuehan Wu, Sudha Singh, Michael Byrne, Justin Wray, Suk-Hee Lee, Jac A Nickoloff and Robert Hromas

    Citation: Cell Division 2014 9:1

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  5. Content type: Review

    CSN6 is one subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), which is an evolutionarily conserved multiprotein complex found in plants and animals and originally described as a repres...

    Authors: Shang-Nuan Zhang, Dong-Sheng Pei and Jun-Nian Zheng

    Citation: Cell Division 2013 8:14

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  6. Content type: Research

    We previously reported that a pool of low molecular weight peptides can be extracted by alkali treatment of DNA preparations obtained from prokaryotic and eukaryotic cells after intensive deproteinization. Thi...

    Authors: Loretta Mancinelli, Teresa Secca, Paula M De Angelis, Francesco Mancini, Matteo Marchesini, Cristiano Marinelli, Lanfranco Barberini and Francesco Grignani

    Citation: Cell Division 2013 8:11

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  7. Content type: Research

    The discovery of molecular markers associated with various breast cancer subtypes has greatly improved the treatment and outcome of breast cancer patients. Unfortunately, breast cancer cells acquire resistance...

    Authors: Katie R Hagen, Xiangbin Zeng, Mi-Young Lee, Shannon Tucker Kahn, Mary Kathryn Harrison Pitner, Sandra S Zaky, Yuan Liu, Ruth M O’Regan, Xingming Deng and Harold I Saavedra

    Citation: Cell Division 2013 8:10

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  8. Content type: Research

    The execution of meiotic nuclear divisions in S. cerevisiae is regulated by protein degradation mediated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase. The correct timing of APC/C activity ...

    Authors: Grace S Tan, Rebecca Lewandowski, Michael J Mallory, Randy Strich and Katrina F Cooper

    Citation: Cell Division 2013 8:9

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  9. Content type: Review

    The liver has a remarkable capacity to regenerate. Even with surgical removal (partial hepatectomy) of 70% of liver mass, the remnant tissue grows to recover the original mass and functions. Liver regeneration...

    Authors: Yuichiro Miyaoka and Atsushi Miyajima

    Citation: Cell Division 2013 8:8

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  10. Content type: Research

    Centrosomes function primarily as microtubule-organizing centres and play a crucial role during mitosis by organizing the bipolar spindle. In addition to this function, centrosomes act as reaction centers wher...

    Authors: Guillaume Chouinard, Isabelle Clément, Julie Lafontaine, Francis Rodier and Estelle Schmitt

    Citation: Cell Division 2013 8:7

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  11. Content type: Methodology

    The yeast Schizosaccharomyces pombe is frequently used as a model for studying the cell cycle. The cells are rod-shaped and divide by medial fission. The process of cell division, or cytokinesis, is controlled by...

    Authors: Daniel Schmitter, Paulina Wachowicz, Daniel Sage, Anastasia Chasapi, Ioannis Xenarios, Viesturs Simanis and Michael Unser

    Citation: Cell Division 2013 8:6

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  12. Content type: Research

    Cell division is positively regulated by cyclin-dependent kinases (CDKs) partnered with cyclins and negatively regulated by CDK inhibitors. In the frog, Xenopus laevis, three types of CDK inhibitors have been des...

    Authors: Xi-Ning Zhu, Dong Hyun Kim, Horng-Ru Lin, Varija N Budhavarapu, Herbert B Rosenbaum, Paul R Mueller and P Renee Yew

    Citation: Cell Division 2013 8:5

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  13. Content type: Research

    During mitosis most nucleolar proteins redistribute to other locales providing an opportunity to study the relationship between nucleolar protein localization and function. Dictyostelium is a model organism for t...

    Authors: Andrew Catalano and Danton H O’Day

    Citation: Cell Division 2013 8:4

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  14. Content type: Research

    Proteins of the BTB-kelch family are known to be involved in multiple biological processes such as migration, cytoskeleton arrangement, regulation of cell morphology, protein ubiquitination and gene expression...

    Authors: Sandra Lührig, Susanne Kolb, Nadine Mellies and Jessica Nolte

    Citation: Cell Division 2013 8:3

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  15. Content type: Commentary

    Our understanding of the structure and function of kinetochores has advanced dramatically over the past 10 years, yet how the plus end of spindle microtubules interacts with the kinetochore and establishes amp...

    Authors: Ngang Heok Tang and Takashi Toda

    Citation: Cell Division 2013 8:2

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  16. Content type: Research

    Infantile hemangioma (IH) is a benign vascular neoplasm that arises from the abnormal proliferation of endothelial cells and enhanced angiogenesis. Recently, propranolol has been found to be effective in the m...

    Authors: Yi Ji, Siyuan Chen, Kai Li, Xianmin Xiao, Shan Zheng and Ting Xu

    Citation: Cell Division 2013 8:1

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  17. Content type: Research

    Cell size homeostasis is a conserved attribute in many eukaryotic species involving a tight regulation between the processes of growth and proliferation. In budding yeast S. cerevisiae, growth to a “critical cell...

    Authors: Huzefa Dungrawala, Hui Hua, Jill Wright, Lesley Abraham, Thivakorn Kasemsri, Anthony McDowell, Jessica Stilwell and Brandt L Schneider

    Citation: Cell Division 2012 7:24

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  18. Content type: Methodology

    Microcell-mediated chromosome transfer (MMCT) was developed to introduce a low number of chromosomes into a host cell. We have designed a novel technique combining part of MMCT with somatic cell nuclear transf...

    Authors: Natalia Canel, Romina Bevacqua, María Inés Hiriart and Daniel Salamone

    Citation: Cell Division 2012 7:23

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  19. Content type: Research

    Previously we have reported on the development of a new mouse anti-titin monoclonal antibody, named MAb Titl 5 H1.1, using the synthetic peptide N-AVNKYGIGEPLESDSVVAK-C which corresponds to an amino acid seque...

    Authors: Aavo-Valdur Mikelsaar, Alar Sünter, Ruth Mikelsaar, Peeter Toomik, Anu Kõiveer, Imre Mikelsaar and Erkki Juronen

    Citation: Cell Division 2012 7:21

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  20. Content type: Review

    A major determinant of cell fate is regulation of cell cycle. Tight regulation of this process is lost during the course of development and progression of various tumors. The ubiquitin-proteasome system (UPS) ...

    Authors: Panagiotis J Vlachostergios, Ioannis A Voutsadakis and Christos N Papandreou

    Citation: Cell Division 2012 7:18

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  21. Content type: Research

    Malignant diseases are responsible of approximately 13% of all deaths each year in the world. Natural products represent a valuable source for the development of novel anticancer drugs. The present study was a...

    Authors: Victor Kuete, Tolga Eichhorn, Benjamin Wiench, Benjamin Krusche and Thomas Efferth

    Citation: Cell Division 2012 7:16

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  22. Content type: Research

    In Schizosaccharomyces pombe the SET domain protein, Set3p - together with its interacting partners, Snt1p, and Hif2p - form a complex that aids in preventing cell division failure upon mild cytokinetic stress. I...

    Authors: Charnpal Grewal, Jack Hickmott, Stefan Rentas and Jim Karagiannis

    Citation: Cell Division 2012 7:13

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  23. Content type: Review

    The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to...

    Authors: Jiri Kohoutek and Dalibor Blazek

    Citation: Cell Division 2012 7:12

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  24. Content type: Research

    Ubiquitin-dependent protein degradation is a critical step in key cell cycle events, such as metaphase-anaphase transition and mitotic exit. The anaphase promoting complex/cyclosome (APC/C) plays a pivotal rol...

    Authors: Olga Nagy, Margit Pál, Andor Udvardy, Christine AM Shirras, Imre Boros, Alan D Shirras and Péter Deák

    Citation: Cell Division 2012 7:9

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  25. Content type: Research

    Xylopia aethiopica, a plant found throughout West Africa, has both nutritional and medicinal uses. The present study aims to characterize the effects of extracts of this plant on cancer cells.

    Authors: Aphrodite T Choumessi, Mathieu Danel, Stefan Chassaing, Isabelle Truchet, Véronique B Penlap, Anatole Constant Pieme, Tazoacha Asonganyi, Bernard Ducommun and Annie Valette

    Citation: Cell Division 2012 7:8

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  26. Content type: Research

    The inorganic phosphate (Pi) transporter, PiT1 (SLC20A1), is ubiquitously expressed in mammalian cells. It has previously been shown that down-regulation of PiT1 severely impaired the proliferation of two transfo...

    Authors: Kristina Byskov, Nina Jensen, Iben Boutrup Kongsfelt, Maria Wielsøe, Lasse Ebdrup Pedersen, Christa Haldrup and Lene Pedersen

    Citation: Cell Division 2012 7:7

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  27. Content type: Research

    The clonal transmission of lineage-specific DNA methylation patterns in a mammalian genome during the cellular division is a crucial biological process controlled by the DNA methyltransferase Dnmt1, mainly. To...

    Authors: Eric Hervouet, Arulraj Nadaradjane, Marine Gueguen, François M Vallette and Pierre-François Cartron

    Citation: Cell Division 2012 7:5

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  28. Content type: Research

    The spindle assembly checkpoint (SAC) inhibits anaphase progression in the presence of insufficient kinetochore-microtubule attachments, but cells can eventually override mitotic arrest by a process known as m...

    Authors: Kazuhiro Toda, Kayoko Naito, Satoru Mase, Masaru Ueno, Masahiro Uritani, Ayumu Yamamoto and Takashi Ushimaru

    Citation: Cell Division 2012 7:4

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  29. Content type: Research

    Aneuploidy has been acknowledged as a major source of genomic instability in cancer, and it is often considered the result of chromosome segregation errors including those caused by defects in genes controllin...

    Authors: Viviana Barra, Tiziana Schillaci, Laura Lentini, Giuseppe Costa and Aldo Di Leonardo

    Citation: Cell Division 2012 7:2

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  30. Content type: Short report

    Cdc5 (polo kinase/Plk1) is a highly conserved key regulator of the S. cerevisiae cell cycle from S-phase until cytokinesis. However, much of the regulatory mechanisms that govern Cdc5 remain to be determined. Cdc...

    Authors: Kobi J Simpson-Lavy and Michael Brandeis

    Citation: Cell Division 2011 6:23

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  31. Content type: Methodology

    Multicellular tumor spheroids are models of increasing interest for cancer and cell biology studies. They allow considering cellular interactions in exploring cell cycle and cell division mechanisms. However, ...

    Authors: Corinne Lorenzo, Céline Frongia, Raphaël Jorand, Jérôme Fehrenbach, Pierre Weiss, Amina Maandhui, Guillaume Gay, Bernard Ducommun and Valérie Lobjois

    Citation: Cell Division 2011 6:22

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