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  1. PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and protein methylation are pivotal modifiers that determine the activation, deactivation or subcellular localization of ...

    Authors: Mingjing He, Zhuan Zhou, Anil A. Shah, Yang Hong, Qianming Chen and Yong Wan

    Citation: Cell Division 2016 11:4

    Content type: Review

    Published on:

  2. The suppressor of cytokine signaling (SOCS) box consists of the BC box and the cullin 5 (Cul5) box, which interact with Elongin BC and Cul5, respectively. SOCS box-containing proteins have ubiquitin ligase act...

    Authors: Fumihiko Okumura, Akiko Joo-Okumura, Kunio Nakatsukasa and Takumi Kamura

    Citation: Cell Division 2016 11:1

    Content type: Review

    Published on:

  3. Curcumin has long been known to posses medicinal properties and recent scientific studies have shown its efficacy in treating cancer. Curcumin is now considered to be a promising anti-cancer agent and studies ...

    Authors: Sayantan Bose, Abir Kumar Panda, Shravanti Mukherjee and Gaurisankar Sa

    Citation: Cell Division 2015 10:6

    Content type: Review

    Published on:

  4. Cullin-RING ubiquitin ligases (CRLs) are regulated by neddylation, which is a post translation modification of the Cullin family proteins. Neddylation of Cul1 activates the ligase through some means of biochem...

    Authors: Gil Bornstein and Chagai Grossman

    Citation: Cell Division 2015 10:5

    Content type: Research

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  5. The ubiquitin family member Sumo has important functions in many cellular processes including DNA repair, transcription and cell division. Numerous studies have shown that Sumo is essential for maintaining cel...

    Authors: Jorrit M. Enserink

    Citation: Cell Division 2015 10:4

    Content type: Review

    Published on:

  6. The cyclin E oncogene activates CDK2 to drive cells from G1 to S phase of the cell cycle to commence DNA replication. It coordinates essential cellular functions with the cell cycle including histone biogenesis, ...

    Authors: Samuel Rogers, Brian S Gloss, Christine S Lee, Claudio Marcelo Sergio, Marcel E Dinger, Elizabeth A Musgrove, Andrew Burgess and Catherine Elizabeth Caldon

    Citation: Cell Division 2015 10:1

    Content type: Short report

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  7. Heterochromatin protein 1 (HP1) is important in the establishment, propagation, and maintenance of constitutive heterochromatin, especially at the pericentromeric region. HP1 might participate in recruiting an...

    Authors: Rodrigo González-Barrios, Ernesto Soto-Reyes, Ricardo Quiroz-Baez, Eunice Fabián-Morales, José Díaz-Chávez, Victor del Castillo, Julia Mendoza, Alejandro López-Saavedra, Clementina Castro and Luis A Herrera

    Citation: Cell Division 2014 9:6

    Content type: Research

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  8. Recent experiments revealing nanoscale electrostatic force generation at kinetochores for chromosome motions have prompted models for interactions between positively charged molecules in kinetochores and negat...

    Authors: Lucian John Gagliardi and Daniel H Shain

    Citation: Cell Division 2014 9:5

    Content type: Commentary

    Published on:

  9. The S-phase checkpoint aims to prevent cells from generation of extensive single-stranded DNA that predisposes to genome instability. The S. cerevisiae complex Tof1/Csm3/Mrc1 acts to restrain the replicative MCM ...

    Authors: Sonya Dimitrova Uzunova, Alexander Stefanov Zarkov, Anna Marianova Ivanova, Stoyno Stefanov Stoynov and Marina Nedelcheva Nedelcheva-Veleva

    Citation: Cell Division 2014 9:4

    Content type: Research

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  10. Centrosome amplification (CA) amongst particular breast cancer subtypes (Her2+ subtype) is associated with genomic instability and aggressive tumor phenotypes. However, changes in signaling pathways associated...

    Authors: Mi-Young Lee, Mihaela Marina, Jamie L King and Harold I Saavedra

    Citation: Cell Division 2014 9:3

    Content type: Research

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  11. Smurf2 is a member of the HECT family of E3 ubiquitin ligases that play important roles in determining the competence of cells to respond to TGF- β/BMP signaling pathway. However, besides TGF-β/BMP pathway, Sm...

    Authors: Diana David, Sankar Jagadeeshan, Ramkumar Hariharan, Asha Sivakumari Nair and Radhakrishna Madhavan Pillai

    Citation: Cell Division 2014 9:2

    Content type: Research

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  12. Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylation of downstream effectors. Metnase (also termed SETMAR) is a SET histone methylase and transposase nuclease protein that p...

    Authors: Elizabeth A Williamson, Yuehan Wu, Sudha Singh, Michael Byrne, Justin Wray, Suk-Hee Lee, Jac A Nickoloff and Robert Hromas

    Citation: Cell Division 2014 9:1

    Content type: Short report

    Published on:

  13. CSN6 is one subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), which is an evolutionarily conserved multiprotein complex found in plants and animals and originally described as a repres...

    Authors: Shang-Nuan Zhang, Dong-Sheng Pei and Jun-Nian Zheng

    Citation: Cell Division 2013 8:14

    Content type: Review

    Published on:

  14. We previously reported that a pool of low molecular weight peptides can be extracted by alkali treatment of DNA preparations obtained from prokaryotic and eukaryotic cells after intensive deproteinization. Thi...

    Authors: Loretta Mancinelli, Teresa Secca, Paula M De Angelis, Francesco Mancini, Matteo Marchesini, Cristiano Marinelli, Lanfranco Barberini and Francesco Grignani

    Citation: Cell Division 2013 8:11

    Content type: Research

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  15. The discovery of molecular markers associated with various breast cancer subtypes has greatly improved the treatment and outcome of breast cancer patients. Unfortunately, breast cancer cells acquire resistance...

    Authors: Katie R Hagen, Xiangbin Zeng, Mi-Young Lee, Shannon Tucker Kahn, Mary Kathryn Harrison Pitner, Sandra S Zaky, Yuan Liu, Ruth M O’Regan, Xingming Deng and Harold I Saavedra

    Citation: Cell Division 2013 8:10

    Content type: Research

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  16. The execution of meiotic nuclear divisions in S. cerevisiae is regulated by protein degradation mediated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase. The correct timing of APC/C activity ...

    Authors: Grace S Tan, Rebecca Lewandowski, Michael J Mallory, Randy Strich and Katrina F Cooper

    Citation: Cell Division 2013 8:9

    Content type: Research

    Published on:

  17. The liver has a remarkable capacity to regenerate. Even with surgical removal (partial hepatectomy) of 70% of liver mass, the remnant tissue grows to recover the original mass and functions. Liver regeneration...

    Authors: Yuichiro Miyaoka and Atsushi Miyajima

    Citation: Cell Division 2013 8:8

    Content type: Review

    Published on:

  18. Centrosomes function primarily as microtubule-organizing centres and play a crucial role during mitosis by organizing the bipolar spindle. In addition to this function, centrosomes act as reaction centers wher...

    Authors: Guillaume Chouinard, Isabelle Clément, Julie Lafontaine, Francis Rodier and Estelle Schmitt

    Citation: Cell Division 2013 8:7

    Content type: Research

    Published on:

  19. The yeast Schizosaccharomyces pombe is frequently used as a model for studying the cell cycle. The cells are rod-shaped and divide by medial fission. The process of cell division, or cytokinesis, is controlled by...

    Authors: Daniel Schmitter, Paulina Wachowicz, Daniel Sage, Anastasia Chasapi, Ioannis Xenarios, Viesturs Simanis and Michael Unser

    Citation: Cell Division 2013 8:6

    Content type: Methodology

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  20. Cell division is positively regulated by cyclin-dependent kinases (CDKs) partnered with cyclins and negatively regulated by CDK inhibitors. In the frog, Xenopus laevis, three types of CDK inhibitors have been des...

    Authors: Xi-Ning Zhu, Dong Hyun Kim, Horng-Ru Lin, Varija N Budhavarapu, Herbert B Rosenbaum, Paul R Mueller and P Renee Yew

    Citation: Cell Division 2013 8:5

    Content type: Research

    Published on:

  21. During mitosis most nucleolar proteins redistribute to other locales providing an opportunity to study the relationship between nucleolar protein localization and function. Dictyostelium is a model organism for t...

    Authors: Andrew Catalano and Danton H O’Day

    Citation: Cell Division 2013 8:4

    Content type: Research

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  22. Proteins of the BTB-kelch family are known to be involved in multiple biological processes such as migration, cytoskeleton arrangement, regulation of cell morphology, protein ubiquitination and gene expression...

    Authors: Sandra Lührig, Susanne Kolb, Nadine Mellies and Jessica Nolte

    Citation: Cell Division 2013 8:3

    Content type: Research

    Published on:

  23. Our understanding of the structure and function of kinetochores has advanced dramatically over the past 10 years, yet how the plus end of spindle microtubules interacts with the kinetochore and establishes amp...

    Authors: Ngang Heok Tang and Takashi Toda

    Citation: Cell Division 2013 8:2

    Content type: Commentary

    Published on:

  24. Infantile hemangioma (IH) is a benign vascular neoplasm that arises from the abnormal proliferation of endothelial cells and enhanced angiogenesis. Recently, propranolol has been found to be effective in the m...

    Authors: Yi Ji, Siyuan Chen, Kai Li, Xianmin Xiao, Shan Zheng and Ting Xu

    Citation: Cell Division 2013 8:1

    Content type: Research

    Published on:

  25. Cell size homeostasis is a conserved attribute in many eukaryotic species involving a tight regulation between the processes of growth and proliferation. In budding yeast S. cerevisiae, growth to a “critical cell...

    Authors: Huzefa Dungrawala, Hui Hua, Jill Wright, Lesley Abraham, Thivakorn Kasemsri, Anthony McDowell, Jessica Stilwell and Brandt L Schneider

    Citation: Cell Division 2012 7:24

    Content type: Research

    Published on:

  26. Microcell-mediated chromosome transfer (MMCT) was developed to introduce a low number of chromosomes into a host cell. We have designed a novel technique combining part of MMCT with somatic cell nuclear transf...

    Authors: Natalia Canel, Romina Bevacqua, María Inés Hiriart and Daniel Salamone

    Citation: Cell Division 2012 7:23

    Content type: Methodology

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  27. Previously we have reported on the development of a new mouse anti-titin monoclonal antibody, named MAb Titl 5 H1.1, using the synthetic peptide N-AVNKYGIGEPLESDSVVAK-C which corresponds to an amino acid seque...

    Authors: Aavo-Valdur Mikelsaar, Alar Sünter, Ruth Mikelsaar, Peeter Toomik, Anu Kõiveer, Imre Mikelsaar and Erkki Juronen

    Citation: Cell Division 2012 7:21

    Content type: Research

    Published on:

  28. A major determinant of cell fate is regulation of cell cycle. Tight regulation of this process is lost during the course of development and progression of various tumors. The ubiquitin-proteasome system (UPS) ...

    Authors: Panagiotis J Vlachostergios, Ioannis A Voutsadakis and Christos N Papandreou

    Citation: Cell Division 2012 7:18

    Content type: Review

    Published on:

  29. Malignant diseases are responsible of approximately 13% of all deaths each year in the world. Natural products represent a valuable source for the development of novel anticancer drugs. The present study was a...

    Authors: Victor Kuete, Tolga Eichhorn, Benjamin Wiench, Benjamin Krusche and Thomas Efferth

    Citation: Cell Division 2012 7:16

    Content type: Research

    Published on:

  30. In Schizosaccharomyces pombe the SET domain protein, Set3p - together with its interacting partners, Snt1p, and Hif2p - form a complex that aids in preventing cell division failure upon mild cytokinetic stress. I...

    Authors: Charnpal Grewal, Jack Hickmott, Stefan Rentas and Jim Karagiannis

    Citation: Cell Division 2012 7:13

    Content type: Research

    Published on:

  31. The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to...

    Authors: Jiri Kohoutek and Dalibor Blazek

    Citation: Cell Division 2012 7:12

    Content type: Review

    Published on:

  32. Ubiquitin-dependent protein degradation is a critical step in key cell cycle events, such as metaphase-anaphase transition and mitotic exit. The anaphase promoting complex/cyclosome (APC/C) plays a pivotal rol...

    Authors: Olga Nagy, Margit Pál, Andor Udvardy, Christine AM Shirras, Imre Boros, Alan D Shirras and Péter Deák

    Citation: Cell Division 2012 7:9

    Content type: Research

    Published on:

  33. Xylopia aethiopica, a plant found throughout West Africa, has both nutritional and medicinal uses. The present study aims to characterize the effects of extracts of this plant on cancer cells.

    Authors: Aphrodite T Choumessi, Mathieu Danel, Stefan Chassaing, Isabelle Truchet, Véronique B Penlap, Anatole Constant Pieme, Tazoacha Asonganyi, Bernard Ducommun and Annie Valette

    Citation: Cell Division 2012 7:8

    Content type: Research

    Published on:

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