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Cell Division

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  1. Content type: Short report

    The cyclin E oncogene activates CDK2 to drive cells from G1 to S phase of the cell cycle to commence DNA replication. It coordinates essential cellular functions with the cell cycle including histone biogenesis, ...

    Authors: Samuel Rogers, Brian S Gloss, Christine S Lee, Claudio Marcelo Sergio, Marcel E Dinger, Elizabeth A Musgrove, Andrew Burgess and Catherine Elizabeth Caldon

    Citation: Cell Division 2015 10:1

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  2. Content type: Research

    Heterochromatin protein 1 (HP1) is important in the establishment, propagation, and maintenance of constitutive heterochromatin, especially at the pericentromeric region. HP1 might participate in recruiting an...

    Authors: Rodrigo González-Barrios, Ernesto Soto-Reyes, Ricardo Quiroz-Baez, Eunice Fabián-Morales, José Díaz-Chávez, Victor del Castillo, Julia Mendoza, Alejandro López-Saavedra, Clementina Castro and Luis A Herrera

    Citation: Cell Division 2014 9:6

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  3. Content type: Commentary

    Recent experiments revealing nanoscale electrostatic force generation at kinetochores for chromosome motions have prompted models for interactions between positively charged molecules in kinetochores and negat...

    Authors: Lucian John Gagliardi and Daniel H Shain

    Citation: Cell Division 2014 9:5

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  4. Content type: Research

    The S-phase checkpoint aims to prevent cells from generation of extensive single-stranded DNA that predisposes to genome instability. The S. cerevisiae complex Tof1/Csm3/Mrc1 acts to restrain the replicative MCM ...

    Authors: Sonya Dimitrova Uzunova, Alexander Stefanov Zarkov, Anna Marianova Ivanova, Stoyno Stefanov Stoynov and Marina Nedelcheva Nedelcheva-Veleva

    Citation: Cell Division 2014 9:4

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  5. Content type: Research

    Centrosome amplification (CA) amongst particular breast cancer subtypes (Her2+ subtype) is associated with genomic instability and aggressive tumor phenotypes. However, changes in signaling pathways associated...

    Authors: Mi-Young Lee, Mihaela Marina, Jamie L King and Harold I Saavedra

    Citation: Cell Division 2014 9:3

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  6. Content type: Research

    Smurf2 is a member of the HECT family of E3 ubiquitin ligases that play important roles in determining the competence of cells to respond to TGF- β/BMP signaling pathway. However, besides TGF-β/BMP pathway, Sm...

    Authors: Diana David, Sankar Jagadeeshan, Ramkumar Hariharan, Asha Sivakumari Nair and Radhakrishna Madhavan Pillai

    Citation: Cell Division 2014 9:2

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  7. Content type: Short report

    Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylation of downstream effectors. Metnase (also termed SETMAR) is a SET histone methylase and transposase nuclease protein that p...

    Authors: Elizabeth A Williamson, Yuehan Wu, Sudha Singh, Michael Byrne, Justin Wray, Suk-Hee Lee, Jac A Nickoloff and Robert Hromas

    Citation: Cell Division 2014 9:1

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  8. Content type: Review

    CSN6 is one subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), which is an evolutionarily conserved multiprotein complex found in plants and animals and originally described as a repres...

    Authors: Shang-Nuan Zhang, Dong-Sheng Pei and Jun-Nian Zheng

    Citation: Cell Division 2013 8:14

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  9. Content type: Research

    We previously reported that a pool of low molecular weight peptides can be extracted by alkali treatment of DNA preparations obtained from prokaryotic and eukaryotic cells after intensive deproteinization. Thi...

    Authors: Loretta Mancinelli, Teresa Secca, Paula M De Angelis, Francesco Mancini, Matteo Marchesini, Cristiano Marinelli, Lanfranco Barberini and Francesco Grignani

    Citation: Cell Division 2013 8:11

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  10. Content type: Research

    The discovery of molecular markers associated with various breast cancer subtypes has greatly improved the treatment and outcome of breast cancer patients. Unfortunately, breast cancer cells acquire resistance...

    Authors: Katie R Hagen, Xiangbin Zeng, Mi-Young Lee, Shannon Tucker Kahn, Mary Kathryn Harrison Pitner, Sandra S Zaky, Yuan Liu, Ruth M O’Regan, Xingming Deng and Harold I Saavedra

    Citation: Cell Division 2013 8:10

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  11. Content type: Research

    The execution of meiotic nuclear divisions in S. cerevisiae is regulated by protein degradation mediated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase. The correct timing of APC/C activity ...

    Authors: Grace S Tan, Rebecca Lewandowski, Michael J Mallory, Randy Strich and Katrina F Cooper

    Citation: Cell Division 2013 8:9

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  12. Content type: Review

    The liver has a remarkable capacity to regenerate. Even with surgical removal (partial hepatectomy) of 70% of liver mass, the remnant tissue grows to recover the original mass and functions. Liver regeneration...

    Authors: Yuichiro Miyaoka and Atsushi Miyajima

    Citation: Cell Division 2013 8:8

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  13. Content type: Research

    Centrosomes function primarily as microtubule-organizing centres and play a crucial role during mitosis by organizing the bipolar spindle. In addition to this function, centrosomes act as reaction centers wher...

    Authors: Guillaume Chouinard, Isabelle Clément, Julie Lafontaine, Francis Rodier and Estelle Schmitt

    Citation: Cell Division 2013 8:7

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  14. Content type: Methodology

    The yeast Schizosaccharomyces pombe is frequently used as a model for studying the cell cycle. The cells are rod-shaped and divide by medial fission. The process of cell division, or cytokinesis, is controlled by...

    Authors: Daniel Schmitter, Paulina Wachowicz, Daniel Sage, Anastasia Chasapi, Ioannis Xenarios, Viesturs Simanis and Michael Unser

    Citation: Cell Division 2013 8:6

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  15. Content type: Research

    Cell division is positively regulated by cyclin-dependent kinases (CDKs) partnered with cyclins and negatively regulated by CDK inhibitors. In the frog, Xenopus laevis, three types of CDK inhibitors have been des...

    Authors: Xi-Ning Zhu, Dong Hyun Kim, Horng-Ru Lin, Varija N Budhavarapu, Herbert B Rosenbaum, Paul R Mueller and P Renee Yew

    Citation: Cell Division 2013 8:5

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  16. Content type: Research

    During mitosis most nucleolar proteins redistribute to other locales providing an opportunity to study the relationship between nucleolar protein localization and function. Dictyostelium is a model organism for t...

    Authors: Andrew Catalano and Danton H O’Day

    Citation: Cell Division 2013 8:4

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  17. Content type: Research

    Proteins of the BTB-kelch family are known to be involved in multiple biological processes such as migration, cytoskeleton arrangement, regulation of cell morphology, protein ubiquitination and gene expression...

    Authors: Sandra Lührig, Susanne Kolb, Nadine Mellies and Jessica Nolte

    Citation: Cell Division 2013 8:3

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  18. Content type: Commentary

    Our understanding of the structure and function of kinetochores has advanced dramatically over the past 10 years, yet how the plus end of spindle microtubules interacts with the kinetochore and establishes amp...

    Authors: Ngang Heok Tang and Takashi Toda

    Citation: Cell Division 2013 8:2

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  19. Content type: Research

    Infantile hemangioma (IH) is a benign vascular neoplasm that arises from the abnormal proliferation of endothelial cells and enhanced angiogenesis. Recently, propranolol has been found to be effective in the m...

    Authors: Yi Ji, Siyuan Chen, Kai Li, Xianmin Xiao, Shan Zheng and Ting Xu

    Citation: Cell Division 2013 8:1

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  20. Content type: Research

    Cell size homeostasis is a conserved attribute in many eukaryotic species involving a tight regulation between the processes of growth and proliferation. In budding yeast S. cerevisiae, growth to a “critical cell...

    Authors: Huzefa Dungrawala, Hui Hua, Jill Wright, Lesley Abraham, Thivakorn Kasemsri, Anthony McDowell, Jessica Stilwell and Brandt L Schneider

    Citation: Cell Division 2012 7:24

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