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  1. In the quest for novel molecular mediators of glioma progression, we studied the regulation of FBXW 7 (hCDC 4/hAGO/SEL 10), its association with survival of patients with glioblastoma and its potential role as a ...

    Authors: Martin Hagedorn, Maylis Delugin, Isabelle Abraldes, Nathalie Allain, Marc-Antoine Belaud-Rotureau, Michelle Turmo, Claude Prigent, Hugues Loiseau, Andréas Bikfalvi and Sophie Javerzat

    Citation: Cell Division 2007 2:9

    Content type: Research

    Published on:

  2. DNA replication must be tightly controlled to prevent initiation of a second round of replication until mitosis is complete. So far, components of the pre-replicative complex (Cdt1, Cdc6 and geminin) were cons...

    Authors: Umasundari Sivaprasad, Yuichi J Machida and Anindya Dutta

    Citation: Cell Division 2007 2:8

    Content type: Commentary

    Published on:

  3. The Fbw7 ubiquitin ligase promotes the rapid degradation of several important oncogenes, such as cyclin E, c-Myc, c-Jun, and Notch. The two fission yeast homologs of Fbw7, pop1 and pop2, have previously been s...

    Authors: Markus Welcker and Bruce E Clurman

    Citation: Cell Division 2007 2:7

    Content type: Research

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  4. "Natura non facit saltum" (nature makes no leap) the Latins used to say, meaning that nature does not like discontinuities. Cells make no exception and indeed any discontinuity in the DNA double helix is promp...

    Authors: Sofia Francia, Robert S Weiss and Fabrizio d'Adda di Fagagna

    Citation: Cell Division 2007 2:3

    Content type: Review

    Published on:

  5. Understanding how molecular motors generate force and move microtubules in mitosis is essential to understanding the physical mechanism of cell division. Recent measurements have shown that one mitotic kinesin...

    Authors: Megan T Valentine, Polly M Fordyce and Steven M Block

    Citation: Cell Division 2006 1:31

    Content type: Review

    Published on:

  6. Regulation of protein stability through the ubiquitin proteasome system is a key mechanism underlying numerous cellular processes. The ubiquitin protein ligases (or E3) are in charge of substrate specificity a...

    Authors: Damien Hermand

    Citation: Cell Division 2006 1:30

    Content type: Commentary

    Published on:

  7. Abp1, and the closely related Cbh1 and Cbh2 are homologous to the human centromere-binding protein CENP-B that has been implicated in the assembly of centromeric heterochromatin. Fission yeast cells lacking Ab...

    Authors: Alexandra M Locovei, Maria-Grazia Spiga, Katsunori Tanaka, Yota Murakami and Gennaro D'Urso

    Citation: Cell Division 2006 1:27

    Content type: Research

    Published on:

  8. Centrosomes are frequently amplified in cancer cells. Increased numbers of centrosomes can give rise to multipolar spindles in mitosis, and thereby lead to the formation of aneuploid daughter cells. However, w...

    Authors: Vlastimil Srsen and Andreas Merdes

    Citation: Cell Division 2006 1:26

    Content type: Review

    Published on:

  9. Cyclin-dependent kinase (CDK)4 is a master integrator that couples mitogenic and antimitogenic extracellular signals with the cell cycle. It is also crucial for many oncogenic transformation processes. In this...

    Authors: Laurence Bockstaele, Katia Coulonval, Hugues Kooken, Sabine Paternot and Pierre P Roger

    Citation: Cell Division 2006 1:25

    Content type: Review

    Published on:

  10. The 2006 Cold Spring Harbor Laboratory meeting on the Mechanisms and Models of Cancer was held August 16–20. The meeting featured several hundred presentations of many short talks (mostly selected from the abs...

    Authors: Andriy Marusyk and James DeGregori

    Citation: Cell Division 2006 1:24

    Content type: Review

    Published on:

  11. A high proliferative capacity of tumor cells usually is associated with shortened patient survival. Disruption of the RB pathway, which is critically involved in regulating the G1 to S cell cycle transition, i...

    Authors: Amel Dib, Timothy R Peterson, Laura Raducha-Grace, Adriana Zingone, Fenghuang Zhan, Ichiro Hanamura, Bart Barlogie, John Shaughnessy Jr and W Michael Kuehl

    Citation: Cell Division 2006 1:23

    Content type: Research

    Published on:

  12. The polypeptide ubiquitin is used in many processes as different as endocytosis, multivesicular body formation, and regulation of gene transcription. Conjugation of a single ubiquitin moiety is typically used ...

    Authors: Tom AM Groothuis, Nico P Dantuma, Jacques Neefjes and Florian A Salomons

    Citation: Cell Division 2006 1:21

    Content type: Commentaries

    Published on:

  13. The identity of the DNA helicase(s) involved in eukaryotic DNA replication is still a matter of debate, but the mini-chromosome maintenance (MCM) proteins are the chief candidate. Six conserved MCM proteins, M...

    Authors: Tomás Aparicio, Arkaitz Ibarra and Juan Méndez

    Citation: Cell Division 2006 1:18

    Content type: Commentaries

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  14. Ubiquitination regulates a host of cellular processes and is well known for its role in progression through the cell division cycle. In budding yeast, cadmium and arsenic stress, the availability of sulfur con...

    Authors: Peter Kaiser, Ning-Yuan Su, James L Yen, Ikram Ouni and Karin Flick

    Citation: Cell Division 2006 1:16

    Content type: Review

    Published on:

  15. Cullin 4 (Cul4), a member of the evolutionally conserved cullin protein family, serves as a scaffold to assemble multisubunit ubiquitin E3 ligase complexes. Cul4 interacts with the Ring finger-containing prote...

    Authors: Qian Dai and Hengbin Wang

    Citation: Cell Division 2006 1:14

    Content type: Commentaries

    Published on:

  16. Post-translational modifiers of the SUMO (S mall U biquitin-related M odifier) family have emerged as key regulators of protein function and fate. While the past few years have seen an enormous increase in knowle...

    Authors: Guillaume Bossis and Frauke Melchior

    Citation: Cell Division 2006 1:13

    Content type: Review

    Published on:

  17. Progression through the mammalian cell cycle is associated with the activity of four cyclin dependent kinases (Cdc2/Cdk1, Cdk2, Cdk4, and Cdk6). Knockout mouse models have provided insight into the interplay o...

    Authors: Cyril Berthet and Philipp Kaldis

    Citation: Cell Division 2006 1:10

    Content type: Commentaries

    Published on:

  18. Cell division is an inherent part of organismal development, and defects in this process can lead to developmental abnormalities as well as cancerous growth. In past decades, much of the basic cell-cycle machi...

    Authors: Mike Boxem

    Citation: Cell Division 2006 1:6

    Content type: Review

    Published on:

  19. In recent years, the general understanding of nutrient sensing and signalling, as well as the knowledge about responses triggered by altered nutrient availability have greatly advanced. While initial studies w...

    Authors: Erwin Swinnen, Valeria Wanke, Johnny Roosen, Bart Smets, Frédérique Dubouloz, Ivo Pedruzzi, Elisabetta Cameroni, Claudio De Virgilio and Joris Winderickx

    Citation: Cell Division 2006 1:3

    Content type: Review

    Published on:

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