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  1. Centrosomes are frequently amplified in cancer cells. Increased numbers of centrosomes can give rise to multipolar spindles in mitosis, and thereby lead to the formation of aneuploid daughter cells. However, w...

    Authors: Vlastimil Srsen and Andreas Merdes
    Citation: Cell Division 2006 1:26
  2. Cyclin-dependent kinase (CDK)4 is a master integrator that couples mitogenic and antimitogenic extracellular signals with the cell cycle. It is also crucial for many oncogenic transformation processes. In this...

    Authors: Laurence Bockstaele, Katia Coulonval, Hugues Kooken, Sabine Paternot and Pierre P Roger
    Citation: Cell Division 2006 1:25
  3. The 2006 Cold Spring Harbor Laboratory meeting on the Mechanisms and Models of Cancer was held August 16–20. The meeting featured several hundred presentations of many short talks (mostly selected from the abs...

    Authors: Andriy Marusyk and James DeGregori
    Citation: Cell Division 2006 1:24
  4. A high proliferative capacity of tumor cells usually is associated with shortened patient survival. Disruption of the RB pathway, which is critically involved in regulating the G1 to S cell cycle transition, i...

    Authors: Amel Dib, Timothy R Peterson, Laura Raducha-Grace, Adriana Zingone, Fenghuang Zhan, Ichiro Hanamura, Bart Barlogie, John Shaughnessy Jr and W Michael Kuehl
    Citation: Cell Division 2006 1:23
  5. The polypeptide ubiquitin is used in many processes as different as endocytosis, multivesicular body formation, and regulation of gene transcription. Conjugation of a single ubiquitin moiety is typically used ...

    Authors: Tom AM Groothuis, Nico P Dantuma, Jacques Neefjes and Florian A Salomons
    Citation: Cell Division 2006 1:21
  6. The identity of the DNA helicase(s) involved in eukaryotic DNA replication is still a matter of debate, but the mini-chromosome maintenance (MCM) proteins are the chief candidate. Six conserved MCM proteins, M...

    Authors: Tomás Aparicio, Arkaitz Ibarra and Juan Méndez
    Citation: Cell Division 2006 1:18
  7. Ubiquitination regulates a host of cellular processes and is well known for its role in progression through the cell division cycle. In budding yeast, cadmium and arsenic stress, the availability of sulfur con...

    Authors: Peter Kaiser, Ning-Yuan Su, James L Yen, Ikram Ouni and Karin Flick
    Citation: Cell Division 2006 1:16
  8. Cullin 4 (Cul4), a member of the evolutionally conserved cullin protein family, serves as a scaffold to assemble multisubunit ubiquitin E3 ligase complexes. Cul4 interacts with the Ring finger-containing prote...

    Authors: Qian Dai and Hengbin Wang
    Citation: Cell Division 2006 1:14
  9. Post-translational modifiers of the SUMO (S mall U biquitin-related M odifier) family have emerged as key regulators of protein function and fate. While the past few years have seen an enormous increase in knowle...

    Authors: Guillaume Bossis and Frauke Melchior
    Citation: Cell Division 2006 1:13
  10. Progression through the mammalian cell cycle is associated with the activity of four cyclin dependent kinases (Cdc2/Cdk1, Cdk2, Cdk4, and Cdk6). Knockout mouse models have provided insight into the interplay o...

    Authors: Cyril Berthet and Philipp Kaldis
    Citation: Cell Division 2006 1:10
  11. Cell division is an inherent part of organismal development, and defects in this process can lead to developmental abnormalities as well as cancerous growth. In past decades, much of the basic cell-cycle machi...

    Authors: Mike Boxem
    Citation: Cell Division 2006 1:6
  12. In recent years, the general understanding of nutrient sensing and signalling, as well as the knowledge about responses triggered by altered nutrient availability have greatly advanced. While initial studies w...

    Authors: Erwin Swinnen, Valeria Wanke, Johnny Roosen, Bart Smets, Frédérique Dubouloz, Ivo Pedruzzi, Elisabetta Cameroni, Claudio De Virgilio and Joris Winderickx
    Citation: Cell Division 2006 1:3

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