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  1. Content type: Review

    Regulation of cyclin levels is important for many cell cycle-related processes and can occur at several different steps of gene expression. Translational regulation of cyclins, which occurs by a variety of reg...

    Authors: Woan-Yuh Tarn and Ming-Chih Lai

    Citation: Cell Division 2011 6:5

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  2. Content type: Research

    Failure to regulate the levels of Cdc25A phosphatase during the cell cycle or during a checkpoint response causes bypass of DNA damage and replication checkpoints resulting in genomic instability and cancer. D...

    Authors: El Mustapha Bahassi, Moying Yin, Susan B Robbins, Ya-Qin Li, Deborah G Conrady, Zhenyu Yuan, Rhett A Kovall, Andrew B Herr and Peter J Stambrook

    Citation: Cell Division 2011 6:4

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  3. Content type: Commentary

    The Skp2 locus encodes two proteins, Skp2 and Skp2B. The role of Skp2 in the ubiquitin-dependent degradation of key regulators of the retinoblastoma protein pathway has been well established. More recent work ...

    Authors: Doris Germain

    Citation: Cell Division 2011 6:1

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  4. Content type: Research

    c-Myb is expressed at high levels in immature progenitors of all the hematopoietic lineages. It is associated with the regulation of proliferation, differentiation and survival of erythroid, myeloid and lympho...

    Authors: Kyoko Kitagawa, Yojiro Kotake, Yoshihiro Hiramatsu, Ning Liu, Sayuri Suzuki, Satoki Nakamura, Akira Kikuchi and Masatoshi Kitagawa

    Citation: Cell Division 2010 5:27

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  5. Content type: Review

    c-Jun activation domain-binding protein-1 (Jab1) acts as a modulator of intracellular signaling and affects cellular proliferation and apoptosis, through its existence as a monomer or as the fifth component of...

    Authors: Terry J Shackleford and Francois X Claret

    Citation: Cell Division 2010 5:26

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  6. Content type: Review

    Polo-like kinase 4 (PLK4) is a unique member of the Polo-like family of kinases that shares little homology with its siblings and has an essential role in centriole duplication. The turn-over of this kinase mu...

    Authors: James E Sillibourne and Michel Bornens

    Citation: Cell Division 2010 5:25

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  7. Content type: Research

    Cdc20 is a highly conserved activator of the anaphase-promoting complex (APC), promoting cell-cycle-regulated ubiquitination and proteolysis of a number of critical cell-cycle-regulatory targets including secu...

    Authors: Jonathan A Robbins and Frederick R Cross

    Citation: Cell Division 2010 5:23

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  8. Content type: Research

    The multi-functional adaptor protein NEDD9/HEF1/Cas-L regulates cell motility, invasion and cell cycle progression, and plays key roles in cancer progression and metastasis. NEDD9 is localized to the centrosom...

    Authors: Finola E Moore, Evan C Osmundson, Jennifer Koblinski, Elena Pugacheva, Erica A Golemis, Dipankar Ray and Hiroaki Kiyokawa

    Citation: Cell Division 2010 5:22

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  9. Content type: Review

    The role of Chk1 in the cellular response to DNA replication stress is well established. However recent work indicates a novel role for Chk1 in the suppression of apoptosis following the disruption of DNA repl...

    Authors: Mark Meuth

    Citation: Cell Division 2010 5:21

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  10. Content type: Commentary

    Ubiquitination involves the attachment of ubiquitin to lysine residues on substrate proteins or itself, which can result in protein monoubiquitination or polyubiquitination. Ubiquitin attachment to different l...

    Authors: Martin Sadowski and Boris Sarcevic

    Citation: Cell Division 2010 5:19

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  11. Content type: Research

    Cellular senescence is a permanent growth arrest that occurs in response to cellular stressors, such as telomere shortening or activation of oncogenes. Although the process of senescence growth arrest is somew...

    Authors: Alyssa L Kennedy, Tony McBryan, Greg H Enders, F Brad Johnson, Rugang Zhang and Peter D Adams

    Citation: Cell Division 2010 5:16

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  12. Content type: Review

    Recent data show that cells from many cancers exhibit massive chromosome instability. The traditional view is that the gradual accumulation of mutations in genes involved in transcriptional regulation and cell...

    Authors: Alexander V Strunnikov

    Citation: Cell Division 2010 5:15

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  13. Content type: Research

    Transcriptional and postranslational regulation of the cell cycle has been widely studied. However, there is scarce knowledge concerning translational control of this process. Several mammalian eukaryotic init...

    Authors: Ana E Higareda-Mendoza and Marco A Pardo-Galván

    Citation: Cell Division 2010 5:10

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  14. Content type: Review

    The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the model organism S. cerevisiae. Research performed during the past decade has significantly improved our understanding of th...

    Authors: Jorrit M Enserink and Richard D Kolodner

    Citation: Cell Division 2010 5:11

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  15. Content type: Review

    p107 and its related family members Rb and p130 are critical regulators of cellular proliferation and tumorigenesis. Due to the extent of functional overlap within the Rb family, it has been difficult to asses...

    Authors: Stacey E Wirt and Julien Sage

    Citation: Cell Division 2010 5:9

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  16. Content type: Commentary

    Regulation of the repair of DNA double-strand breaks by homologous recombination is extremely important for both cell viability and the maintenance of genomic integrity. Modulation of double-strand break repai...

    Authors: Jacqueline H Barlow and Rodney Rothstein

    Citation: Cell Division 2010 5:7

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  17. Content type: Commentary

    Pancreatic β-cells are metabolic sensors involved in the control of glucose homeostasis. This particular cell type controls insulin secretion through a fine-tuned process, which dregulation have important path...

    Authors: Lluis Fajas, Emilie Blanchet and Jean-Sébastien Annicotte

    Citation: Cell Division 2010 5:6

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  18. Content type: Review

    Senescence and mitotic catastrophe (MC) are two distinct crucial non-apoptotic mechanisms, often triggered in cancer cells and tissues in response to anti-cancer drugs. Chemotherapeuticals and myriad other fac...

    Authors: Richa Singh, Jasmine George and Yogeshwer Shukla

    Citation: Cell Division 2010 5:4

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    The Retraction Note to this article has been published in Cell Division 2012 7:15

  19. Content type: Commentary

    Oncogenic proliferative signals are coupled to a variety of growth inhibitory processes. In cultured primary human fibroblasts, for example, ectopic expression of oncogenic Ras or its downstream mediator initi...

    Authors: Naoko Ohtani, Kimi Yamakoshi, Akiko Takahashi and Eiji Hara

    Citation: Cell Division 2010 5:1

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  20. Content type: Review

    Cancer is a multifaceted disease that results from dysregulated normal cellular signaling networks caused by genetic, genomic and epigenetic alterations at cell or tissue levels. Uncovering the underlying prot...

    Authors: David Y Zhang, Fei Ye, Ling Gao, Xiaoliang Liu, Xin Zhao, Yufang Che, Hongxia Wang, Libo Wang, Josephine Wu, Dong Song, Wei Liu, Hong Xu, Bo Jiang, Weijia Zhang, Jinhua Wang and Peng Lee

    Citation: Cell Division 2009 4:20

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  21. Content type: Review

    Regulation of gene expression is essential to all aspects of physiological processes in single-cell as well as multicellular organisms. It gives ultimately cells the ability to efficiently respond to extra- an...

    Authors: Jiri Kohoutek

    Citation: Cell Division 2009 4:19

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  22. Content type: Research

    The yeast cell cycle is largely controlled by the cyclin-dependent kinase (CDK) Cdc28. Recent evidence suggests that both CDK complex stability as well as function during mitosis is determined by precise regul...

    Authors: Brian TD Tobe, Ana A Kitazono, Jacqueline S Garcia, Renee A Gerber, Brooke J Bevis, John S Choy, Daniel Chasman and Stephen J Kron

    Citation: Cell Division 2009 4:12

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  23. Content type: Commentary

    Once it was believed that Cdk2 was the master regulator of S phase entry. Gene knockout mouse studies of cell cycle regulators revealed that Cdk2 is dispensable for S phase initiation and progression whereby C...

    Authors: Ande Satyanarayana and Philipp Kaldis

    Citation: Cell Division 2009 4:9

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  24. Content type: Review

    Chk1 is a serine/threonine protein kinase that is the effector of the G2 DNA damage checkpoint. Chk1 homologs have a highly conserved N-terminal kinase domain, and a less conserved C-terminal regulatory domain...

    Authors: Claudia Tapia-Alveal, Teresa M Calonge and Matthew J O'Connell

    Citation: Cell Division 2009 4:8

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  25. Content type: Research

    The fish oil-derived ω-3 fatty acids, like docosahexanoic (DHA), claim a plethora of health benefits. We currently evaluated the antitumor effects of DHA, alone or in combination with cisplatin (CP) in the EAC...

    Authors: ME El-Mesery, MM Al-Gayyar, HA Salem, MM Darweish and AM El-Mowafy

    Citation: Cell Division 2009 4:6

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  26. Content type: Review

    Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlapping functions in the cell cycle progression. Plk1 plays a key role...

    Authors: Lin-Yu Lu and Xiaochun Yu

    Citation: Cell Division 2009 4:4

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