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  1. The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to...

    Authors: Jiri Kohoutek and Dalibor Blazek

    Citation: Cell Division 2012 7:12

    Content type: Review

    Published on:

  4. Ubiquitin-dependent protein degradation is a critical step in key cell cycle events, such as metaphase-anaphase transition and mitotic exit. The anaphase promoting complex/cyclosome (APC/C) plays a pivotal rol...

    Authors: Olga Nagy, Margit Pál, Andor Udvardy, Christine AM Shirras, Imre Boros, Alan D Shirras and Péter Deák

    Citation: Cell Division 2012 7:9

    Content type: Research

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  5. Xylopia aethiopica, a plant found throughout West Africa, has both nutritional and medicinal uses. The present study aims to characterize the effects of extracts of this plant on cancer cells.

    Authors: Aphrodite T Choumessi, Mathieu Danel, Stefan Chassaing, Isabelle Truchet, Véronique B Penlap, Anatole Constant Pieme, Tazoacha Asonganyi, Bernard Ducommun and Annie Valette

    Citation: Cell Division 2012 7:8

    Content type: Research

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  6. The inorganic phosphate (Pi) transporter, PiT1 (SLC20A1), is ubiquitously expressed in mammalian cells. It has previously been shown that down-regulation of PiT1 severely impaired the proliferation of two transfo...

    Authors: Kristina Byskov, Nina Jensen, Iben Boutrup Kongsfelt, Maria Wielsøe, Lasse Ebdrup Pedersen, Christa Haldrup and Lene Pedersen

    Citation: Cell Division 2012 7:7

    Content type: Research

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  8. The clonal transmission of lineage-specific DNA methylation patterns in a mammalian genome during the cellular division is a crucial biological process controlled by the DNA methyltransferase Dnmt1, mainly. To...

    Authors: Eric Hervouet, Arulraj Nadaradjane, Marine Gueguen, François M Vallette and Pierre-François Cartron

    Citation: Cell Division 2012 7:5

    Content type: Research

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  9. The spindle assembly checkpoint (SAC) inhibits anaphase progression in the presence of insufficient kinetochore-microtubule attachments, but cells can eventually override mitotic arrest by a process known as m...

    Authors: Kazuhiro Toda, Kayoko Naito, Satoru Mase, Masaru Ueno, Masahiro Uritani, Ayumu Yamamoto and Takashi Ushimaru

    Citation: Cell Division 2012 7:4

    Content type: Research

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  11. Aneuploidy has been acknowledged as a major source of genomic instability in cancer, and it is often considered the result of chromosome segregation errors including those caused by defects in genes controllin...

    Authors: Viviana Barra, Tiziana Schillaci, Laura Lentini, Giuseppe Costa and Aldo Di Leonardo

    Citation: Cell Division 2012 7:2

    Content type: Research

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  12. The maintenance of genomic integrity is essential for cell viability. Complex signalling pathways (DNA integrity checkpoints) mediate the response to genotoxic stresses. Identifying new functions involved in t...

    Authors: María Soriano-Carot, M Carmen Bañó and J Carlos Igual

    Citation: Cell Division 2012 7:1

    Content type: Research

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  13. Cdc5 (polo kinase/Plk1) is a highly conserved key regulator of the S. cerevisiae cell cycle from S-phase until cytokinesis. However, much of the regulatory mechanisms that govern Cdc5 remain to be determined. Cdc...

    Authors: Kobi J Simpson-Lavy and Michael Brandeis

    Citation: Cell Division 2011 6:23

    Content type: Short report

    Published on:

  14. Multicellular tumor spheroids are models of increasing interest for cancer and cell biology studies. They allow considering cellular interactions in exploring cell cycle and cell division mechanisms. However, ...

    Authors: Corinne Lorenzo, Céline Frongia, Raphaël Jorand, Jérôme Fehrenbach, Pierre Weiss, Amina Maandhui, Guillaume Gay, Bernard Ducommun and Valérie Lobjois

    Citation: Cell Division 2011 6:22

    Content type: Methodology

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  21. Eukaryotic chromatin is a combination of DNA and histone proteins. It is established fact that epigenetic mechanisms are associated with DNA and histones. Initial studies emphasize on core histones association...

    Authors: Waqar Ahmad, Khadija Shabbiri, Noreen Nazar, Shazia Nazar, Saba Qaiser and Mirza Abid Shabbir Mughal

    Citation: Cell Division 2011 6:15

    Content type: Research

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  22. Recently, interest in phytochemicals from traditional Chinese medicinal herbs with the capability to inhibit cancer cells growth and proliferation has been growing rapidly due to their nontoxic nature. Dysosma ve...

    Authors: Xiaoqiang Xu, Xiuhong Gao, Linhong Jin, Pinaki S Bhadury, Kai Yuan, Deyu Hu, Baoan Song and Song Yang

    Citation: Cell Division 2011 6:14

    Content type: Research

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  23. Histone post-translational modifications are critical for gene expression and cell viability. A broad spectrum of histone lysine residues have been identified in yeast that are targeted by a variety of modifyi...

    Authors: Azharul Islam, Emma L Turner, Johannes Menzel, Mackenzie E Malo and Troy AA Harkness

    Citation: Cell Division 2011 6:13

    Content type: Research

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  24. For proper tissue morphogenesis, cell divisions and cell fate decisions must be tightly and coordinately regulated. One elegant way to accomplish this is to couple them with asymmetric cell divisions. Progenit...

    Authors: Samriddha Ray and Terry Lechler

    Citation: Cell Division 2011 6:12

    Content type: Commentary

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  26. The vast majority of cells, from prokaryotes up to vertebrate organisms, spend most of their time in quiescence, a state defined as a temporary and reversible absence of proliferation. Establishing the quiesce...

    Authors: Bertrand Daignan-Fornier and Isabelle Sagot

    Citation: Cell Division 2011 6:10

    Content type: Commentary

    Published on:

  29. The S73/S97/loop motif is a hallmark of the Cdc34 family of E2 ubiquitin-conjugating enzymes that together with the SCF E3 ubiquitin ligases promote degradation of proteins involved in cell cycle and growth regul...

    Authors: Agnieszka Lass, Ross Cocklin, Kenneth M Scaglione, Michael Skowyra, Sergey Korolev, Mark Goebl and Dorota Skowyra

    Citation: Cell Division 2011 6:7

    Content type: Research

    Published on:

    The Erratum to this article has been published in Cell Division 2016 11:13

  31. Regulation of cyclin levels is important for many cell cycle-related processes and can occur at several different steps of gene expression. Translational regulation of cyclins, which occurs by a variety of reg...

    Authors: Woan-Yuh Tarn and Ming-Chih Lai

    Citation: Cell Division 2011 6:5

    Content type: Review

    Published on:

  32. Failure to regulate the levels of Cdc25A phosphatase during the cell cycle or during a checkpoint response causes bypass of DNA damage and replication checkpoints resulting in genomic instability and cancer. D...

    Authors: El Mustapha Bahassi, Moying Yin, Susan B Robbins, Ya-Qin Li, Deborah G Conrady, Zhenyu Yuan, Rhett A Kovall, Andrew B Herr and Peter J Stambrook

    Citation: Cell Division 2011 6:4

    Content type: Research

    Published on:

  35. The Skp2 locus encodes two proteins, Skp2 and Skp2B. The role of Skp2 in the ubiquitin-dependent degradation of key regulators of the retinoblastoma protein pathway has been well established. More recent work ...

    Authors: Doris Germain

    Citation: Cell Division 2011 6:1

    Content type: Commentary

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  37. c-Myb is expressed at high levels in immature progenitors of all the hematopoietic lineages. It is associated with the regulation of proliferation, differentiation and survival of erythroid, myeloid and lympho...

    Authors: Kyoko Kitagawa, Yojiro Kotake, Yoshihiro Hiramatsu, Ning Liu, Sayuri Suzuki, Satoki Nakamura, Akira Kikuchi and Masatoshi Kitagawa

    Citation: Cell Division 2010 5:27

    Content type: Research

    Published on:

  38. c-Jun activation domain-binding protein-1 (Jab1) acts as a modulator of intracellular signaling and affects cellular proliferation and apoptosis, through its existence as a monomer or as the fifth component of...

    Authors: Terry J Shackleford and Francois X Claret

    Citation: Cell Division 2010 5:26

    Content type: Review

    Published on:

  39. Polo-like kinase 4 (PLK4) is a unique member of the Polo-like family of kinases that shares little homology with its siblings and has an essential role in centriole duplication. The turn-over of this kinase mu...

    Authors: James E Sillibourne and Michel Bornens

    Citation: Cell Division 2010 5:25

    Content type: Review

    Published on:

  41. Cdc20 is a highly conserved activator of the anaphase-promoting complex (APC), promoting cell-cycle-regulated ubiquitination and proteolysis of a number of critical cell-cycle-regulatory targets including secu...

    Authors: Jonathan A Robbins and Frederick R Cross

    Citation: Cell Division 2010 5:23

    Content type: Research

    Published on:

  42. The multi-functional adaptor protein NEDD9/HEF1/Cas-L regulates cell motility, invasion and cell cycle progression, and plays key roles in cancer progression and metastasis. NEDD9 is localized to the centrosom...

    Authors: Finola E Moore, Evan C Osmundson, Jennifer Koblinski, Elena Pugacheva, Erica A Golemis, Dipankar Ray and Hiroaki Kiyokawa

    Citation: Cell Division 2010 5:22

    Content type: Research

    Published on:

  43. The role of Chk1 in the cellular response to DNA replication stress is well established. However recent work indicates a novel role for Chk1 in the suppression of apoptosis following the disruption of DNA repl...

    Authors: Mark Meuth

    Citation: Cell Division 2010 5:21

    Content type: Review

    Published on:

  45. Ubiquitination involves the attachment of ubiquitin to lysine residues on substrate proteins or itself, which can result in protein monoubiquitination or polyubiquitination. Ubiquitin attachment to different l...

    Authors: Martin Sadowski and Boris Sarcevic

    Citation: Cell Division 2010 5:19

    Content type: Commentary

    Published on:

  48. Cellular senescence is a permanent growth arrest that occurs in response to cellular stressors, such as telomere shortening or activation of oncogenes. Although the process of senescence growth arrest is somew...

    Authors: Alyssa L Kennedy, Tony McBryan, Greg H Enders, F Brad Johnson, Rugang Zhang and Peter D Adams

    Citation: Cell Division 2010 5:16

    Content type: Research

    Published on:

  49. Recent data show that cells from many cancers exhibit massive chromosome instability. The traditional view is that the gradual accumulation of mutations in genes involved in transcriptional regulation and cell...

    Authors: Alexander V Strunnikov

    Citation: Cell Division 2010 5:15

    Content type: Review

    Published on:

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