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  1. Regulation of the repair of DNA double-strand breaks by homologous recombination is extremely important for both cell viability and the maintenance of genomic integrity. Modulation of double-strand break repai...

    Authors: Jacqueline H Barlow and Rodney Rothstein

    Citation: Cell Division 2010 5:7

    Content type: Commentary

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  2. Pancreatic β-cells are metabolic sensors involved in the control of glucose homeostasis. This particular cell type controls insulin secretion through a fine-tuned process, which dregulation have important path...

    Authors: Lluis Fajas, Emilie Blanchet and Jean-Sébastien Annicotte

    Citation: Cell Division 2010 5:6

    Content type: Commentary

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  3. Senescence and mitotic catastrophe (MC) are two distinct crucial non-apoptotic mechanisms, often triggered in cancer cells and tissues in response to anti-cancer drugs. Chemotherapeuticals and myriad other fac...

    Authors: Richa Singh, Jasmine George and Yogeshwer Shukla

    Citation: Cell Division 2010 5:4

    Content type: Review

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    The Retraction Note to this article has been published in Cell Division 2012 7:15

  4. Oncogenic proliferative signals are coupled to a variety of growth inhibitory processes. In cultured primary human fibroblasts, for example, ectopic expression of oncogenic Ras or its downstream mediator initi...

    Authors: Naoko Ohtani, Kimi Yamakoshi, Akiko Takahashi and Eiji Hara

    Citation: Cell Division 2010 5:1

    Content type: Commentary

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  5. Cancer is a multifaceted disease that results from dysregulated normal cellular signaling networks caused by genetic, genomic and epigenetic alterations at cell or tissue levels. Uncovering the underlying prot...

    Authors: David Y Zhang, Fei Ye, Ling Gao, Xiaoliang Liu, Xin Zhao, Yufang Che, Hongxia Wang, Libo Wang, Josephine Wu, Dong Song, Wei Liu, Hong Xu, Bo Jiang, Weijia Zhang, Jinhua Wang and Peng Lee

    Citation: Cell Division 2009 4:20

    Content type: Review

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  6. Regulation of gene expression is essential to all aspects of physiological processes in single-cell as well as multicellular organisms. It gives ultimately cells the ability to efficiently respond to extra- an...

    Authors: Jiri Kohoutek

    Citation: Cell Division 2009 4:19

    Content type: Review

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  7. The yeast cell cycle is largely controlled by the cyclin-dependent kinase (CDK) Cdc28. Recent evidence suggests that both CDK complex stability as well as function during mitosis is determined by precise regul...

    Authors: Brian TD Tobe, Ana A Kitazono, Jacqueline S Garcia, Renee A Gerber, Brooke J Bevis, John S Choy, Daniel Chasman and Stephen J Kron

    Citation: Cell Division 2009 4:12

    Content type: Research

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  8. Once it was believed that Cdk2 was the master regulator of S phase entry. Gene knockout mouse studies of cell cycle regulators revealed that Cdk2 is dispensable for S phase initiation and progression whereby C...

    Authors: Ande Satyanarayana and Philipp Kaldis

    Citation: Cell Division 2009 4:9

    Content type: Commentary

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  9. Chk1 is a serine/threonine protein kinase that is the effector of the G2 DNA damage checkpoint. Chk1 homologs have a highly conserved N-terminal kinase domain, and a less conserved C-terminal regulatory domain...

    Authors: Claudia Tapia-Alveal, Teresa M Calonge and Matthew J O'Connell

    Citation: Cell Division 2009 4:8

    Content type: Review

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  10. The fish oil-derived ω-3 fatty acids, like docosahexanoic (DHA), claim a plethora of health benefits. We currently evaluated the antitumor effects of DHA, alone or in combination with cisplatin (CP) in the EAC...

    Authors: ME El-Mesery, MM Al-Gayyar, HA Salem, MM Darweish and AM El-Mowafy

    Citation: Cell Division 2009 4:6

    Content type: Research

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  11. Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlapping functions in the cell cycle progression. Plk1 plays a key role...

    Authors: Lin-Yu Lu and Xiaochun Yu

    Citation: Cell Division 2009 4:4

    Content type: Review

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  12. The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase playing essential functions in mitosis. It is conserved from yeast to human and relies on two adaptor proteins, Cdc20 and...

    Authors: Min Li and Pumin Zhang

    Citation: Cell Division 2009 4:2

    Content type: Review

    Published on:

  13. Increasing knowledge on the cell cycle deregulations in cancers has promoted the introduction of phytochemicals, which can either modulate signaling pathways leading to cell cycle regulation or directly alter ...

    Authors: Gaurisankar Sa and Tanya Das

    Citation: Cell Division 2008 3:14

    Content type: Review

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  14. The retinoblastoma protein, Rb, was one of the first tumor suppressor genes identified as a result of the familial syndrome retinoblastoma. In the period since its identification and cloning a large number of ...

    Authors: Carl R Walkley, Vijay G Sankaran and Stuart H Orkin

    Citation: Cell Division 2008 3:13

    Content type: Review

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  15. The yeast SCFMet30 ubiquitin ligase plays a critical role in cell division by regulating the Met4 transcriptional activator of genes that control the uptake and assimilation of sulfur into methionine and S-adenos...

    Authors: Srikripa Chandrasekaran and Dorota Skowyra

    Citation: Cell Division 2008 3:11

    Content type: Review

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  16. Novel murine models of retinoblastoma based on Rb gene deletion in concert with inactivation of Rb family members have recently been developed. These new Rb knockout models of retinoblastoma provide excellent too...

    Authors: David MacPherson

    Citation: Cell Division 2008 3:9

    Content type: Review

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  17. Monoubiquitination of H2A is a major histone modification in mammalian cells. Understanding how monoubiquitinated H2A (uH2A) regulates DNA-based processes in the context of chromatin is a challenging question....

    Authors: Joseph HA Vissers, Francesco Nicassio, Maarten van Lohuizen, Pier Paolo Di Fiore and Elisabetta Citterio

    Citation: Cell Division 2008 3:8

    Content type: Review

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  18. The spindle checkpoint delays the onset of anaphase until all sister chromatids are aligned properly at the metaphase plate. To investigate the role san-1, the MAD3 homologue, has in Caenorhabditis elegans embryo...

    Authors: Vinita A Hajeri, Anil M Stewart, Landon L Moore and Pamela A Padilla

    Citation: Cell Division 2008 3:6

    Content type: Research

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  19. SUMO proteins are small ubiquitin-like modifiers found in all eukaryotes that become covalently conjugated to other cellular proteins. The SUMO conjugation pathway is biochemically similar to ubiquitin conjuga...

    Authors: Mary Dasso

    Citation: Cell Division 2008 3:5

    Content type: Review

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  20. The cell cycle is tightly controlled to ensure that replication origins fire only once per cycle and that consecutive S-phases are separated by mitosis. When controls fail, DNA over-replication ensues: individ...

    Authors: Andrew CG Porter

    Citation: Cell Division 2008 3:3

    Content type: Review

    Published on:

  21. 14-3-3 proteins are a family of adaptor proteins that participate in a wide variety of cellular processes. Recent evidence indicates that the expression levels of these proteins are elevated in some human tumo...

    Authors: Sophia W Hong, Wenqing Qi, Marc Brabant, Giovanni Bosco and Jesse D Martinez

    Citation: Cell Division 2008 3:2

    Content type: Research

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  22. Problems with whole-culture synchronization methods for the study of the cell cycle have led to the need for an analysis of protein content during the cell cycle of cells that have not been starved or inhibite...

    Authors: Stephen Cooper, Michelle Paulsen, Mats Ljungman, Dang Vu-Phan, Duyang Kim and Mariam Gonzalez-Hernandez

    Citation: Cell Division 2007 2:28

    Content type: Research

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  23. The NIMA-related kinases represent a family of serine/threonine kinases implicated in cell cycle control. The founding member of this family, the NIMA kinase of Aspergillus nidulans, as well as the fission yeast ...

    Authors: Laura O'Regan, Joelle Blot and Andrew M Fry

    Citation: Cell Division 2007 2:25

    Content type: Review

    Published on:

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