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  1. Content type: Review

    The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase playing essential functions in mitosis. It is conserved from yeast to human and relies on two adaptor proteins, Cdc20 and...

    Authors: Min Li and Pumin Zhang

    Citation: Cell Division 2009 4:2

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  2. Content type: Review

    Increasing knowledge on the cell cycle deregulations in cancers has promoted the introduction of phytochemicals, which can either modulate signaling pathways leading to cell cycle regulation or directly alter ...

    Authors: Gaurisankar Sa and Tanya Das

    Citation: Cell Division 2008 3:14

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  3. Content type: Review

    The retinoblastoma protein, Rb, was one of the first tumor suppressor genes identified as a result of the familial syndrome retinoblastoma. In the period since its identification and cloning a large number of ...

    Authors: Carl R Walkley, Vijay G Sankaran and Stuart H Orkin

    Citation: Cell Division 2008 3:13

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  4. Content type: Review

    The yeast SCFMet30 ubiquitin ligase plays a critical role in cell division by regulating the Met4 transcriptional activator of genes that control the uptake and assimilation of sulfur into methionine and S-adenos...

    Authors: Srikripa Chandrasekaran and Dorota Skowyra

    Citation: Cell Division 2008 3:11

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  5. Content type: Review

    Novel murine models of retinoblastoma based on Rb gene deletion in concert with inactivation of Rb family members have recently been developed. These new Rb knockout models of retinoblastoma provide excellent too...

    Authors: David MacPherson

    Citation: Cell Division 2008 3:9

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  6. Content type: Review

    Monoubiquitination of H2A is a major histone modification in mammalian cells. Understanding how monoubiquitinated H2A (uH2A) regulates DNA-based processes in the context of chromatin is a challenging question....

    Authors: Joseph HA Vissers, Francesco Nicassio, Maarten van Lohuizen, Pier Paolo Di Fiore and Elisabetta Citterio

    Citation: Cell Division 2008 3:8

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  7. Content type: Research

    The spindle checkpoint delays the onset of anaphase until all sister chromatids are aligned properly at the metaphase plate. To investigate the role san-1, the MAD3 homologue, has in Caenorhabditis elegans embryo...

    Authors: Vinita A Hajeri, Anil M Stewart, Landon L Moore and Pamela A Padilla

    Citation: Cell Division 2008 3:6

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  8. Content type: Review

    SUMO proteins are small ubiquitin-like modifiers found in all eukaryotes that become covalently conjugated to other cellular proteins. The SUMO conjugation pathway is biochemically similar to ubiquitin conjuga...

    Authors: Mary Dasso

    Citation: Cell Division 2008 3:5

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  9. Content type: Review

    The cell cycle is tightly controlled to ensure that replication origins fire only once per cycle and that consecutive S-phases are separated by mitosis. When controls fail, DNA over-replication ensues: individ...

    Authors: Andrew CG Porter

    Citation: Cell Division 2008 3:3

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  10. Content type: Research

    14-3-3 proteins are a family of adaptor proteins that participate in a wide variety of cellular processes. Recent evidence indicates that the expression levels of these proteins are elevated in some human tumo...

    Authors: Sophia W Hong, Wenqing Qi, Marc Brabant, Giovanni Bosco and Jesse D Martinez

    Citation: Cell Division 2008 3:2

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  11. Content type: Research

    Problems with whole-culture synchronization methods for the study of the cell cycle have led to the need for an analysis of protein content during the cell cycle of cells that have not been starved or inhibite...

    Authors: Stephen Cooper, Michelle Paulsen, Mats Ljungman, Dang Vu-Phan, Duyang Kim and Mariam Gonzalez-Hernandez

    Citation: Cell Division 2007 2:28

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  12. Content type: Review

    The NIMA-related kinases represent a family of serine/threonine kinases implicated in cell cycle control. The founding member of this family, the NIMA kinase of Aspergillus nidulans, as well as the fission yeast ...

    Authors: Laura O'Regan, Joelle Blot and Andrew M Fry

    Citation: Cell Division 2007 2:25

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  13. Content type: Review

    Completion of DNA replication before mitosis is essential for genome stability and cell viability. Cellular controls called checkpoints act as surveillance mechanisms capable of detecting errors and blocking c...

    Authors: Jordi Torres-Rosell, Giacomo De Piccoli and Luis Aragón

    Citation: Cell Division 2007 2:19

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  14. Content type: Review

    In eukaryotic organisms, chromosomes are spatially organized within the nucleus. Such nuclear architecture provides a physical framework for the genetic activities of chromosomes, and changes its functional or...

    Authors: Haruhiko Asakawa, Tokuko Haraguchi and Yasushi Hiraoka

    Citation: Cell Division 2007 2:17

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  15. Content type: Review

    Many meiosis-specific proteins in Schizosaccharomyces pombe contain coiled-coil motifs which play essential roles for meiotic progression. For example, the coiled-coil motifs present in Meu13 and Mcp7 are require...

    Authors: Ayami Ohtaka, Takamune T Saito, Daisuke Okuzaki and Hiroshi Nojima

    Citation: Cell Division 2007 2:14

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  16. Content type: Review

    The cyclin kinase inhibitor p27kip1 acts as a potent tumor supressor protein in a variety of human cancers. Its expression levels correlate closely with the overall prognosis of the affected patient and often pre...

    Authors: Irina Nickeleit, Steffen Zender, Uta Kossatz and Nisar P Malek

    Citation: Cell Division 2007 2:13

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  17. Content type: Review

    Movement through the cell cycle is controlled by the temporally and spatially ordered activation of cyclin-dependent kinases paired with their respective cyclin binding partners. Cell cycle events occur in a s...

    Authors: Jennifer A Perry and Sally Kornbluth

    Citation: Cell Division 2007 2:12

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  18. Content type: Review

    Ubiquitin is a highly versatile post-translational modification that controls virtually all types of cellular events. Over the past ten years we have learned that diverse forms of ubiquitin modifications and o...

    Authors: Tanja Woelk, Sara Sigismund, Lorenza Penengo and Simona Polo

    Citation: Cell Division 2007 2:11

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  19. Content type: Research

    In the quest for novel molecular mediators of glioma progression, we studied the regulation of FBXW 7 (hCDC 4/hAGO/SEL 10), its association with survival of patients with glioblastoma and its potential role as a ...

    Authors: Martin Hagedorn, Maylis Delugin, Isabelle Abraldes, Nathalie Allain, Marc-Antoine Belaud-Rotureau, Michelle Turmo, Claude Prigent, Hugues Loiseau, Andréas Bikfalvi and Sophie Javerzat

    Citation: Cell Division 2007 2:9

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  20. Content type: Commentary

    DNA replication must be tightly controlled to prevent initiation of a second round of replication until mitosis is complete. So far, components of the pre-replicative complex (Cdt1, Cdc6 and geminin) were cons...

    Authors: Umasundari Sivaprasad, Yuichi J Machida and Anindya Dutta

    Citation: Cell Division 2007 2:8

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  21. Content type: Research

    The Fbw7 ubiquitin ligase promotes the rapid degradation of several important oncogenes, such as cyclin E, c-Myc, c-Jun, and Notch. The two fission yeast homologs of Fbw7, pop1 and pop2, have previously been s...

    Authors: Markus Welcker and Bruce E Clurman

    Citation: Cell Division 2007 2:7

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  22. Content type: Review

    "Natura non facit saltum" (nature makes no leap) the Latins used to say, meaning that nature does not like discontinuities. Cells make no exception and indeed any discontinuity in the DNA double helix is promp...

    Authors: Sofia Francia, Robert S Weiss and Fabrizio d'Adda di Fagagna

    Citation: Cell Division 2007 2:3

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  23. Content type: Review

    Understanding how molecular motors generate force and move microtubules in mitosis is essential to understanding the physical mechanism of cell division. Recent measurements have shown that one mitotic kinesin...

    Authors: Megan T Valentine, Polly M Fordyce and Steven M Block

    Citation: Cell Division 2006 1:31

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  24. Content type: Commentary

    Regulation of protein stability through the ubiquitin proteasome system is a key mechanism underlying numerous cellular processes. The ubiquitin protein ligases (or E3) are in charge of substrate specificity a...

    Authors: Damien Hermand

    Citation: Cell Division 2006 1:30

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